Angiotensinogen fragment 1-13, also known as angiotensin I, is a peptide derived from the larger precursor angiotensinogen, which is produced in the liver. This fragment consists of 13 amino acids and plays a crucial role in the renin-angiotensin system, which regulates blood pressure and fluid balance in the body. The sequence of this peptide is critical for its biological activity, as it serves as a substrate for the enzyme renin, leading to the production of angiotensin II, a potent vasoconstrictor. Angiotensin I itself is biologically inactive but is converted to angiotensin II by the action of angiotensin-converting enzyme (ACE). The CAS number 82048-97-3 uniquely identifies this specific peptide in chemical databases. In terms of characteristics, angiotensin I is typically soluble in water and exhibits stability under physiological conditions, making it relevant for various research and clinical applications, particularly in studies related to cardiovascular health and hypertension.

angiotensinogen fragment 1-13 human

82048-97-3: Angiotensinogen fragment 1-13, also known as angiotensin I, is a peptide derived from the larger precursor angiotensinogen, which is produced in the liver. This fragment consists of 13 amino acids and plays a crucial role in the renin-angiotensin system, which regulates blood pressure and fluid balance in the body. The sequence of this peptide is critical for its biological activity, as it serves as a substrate for the enzyme renin, leading to the production of angiotensin II, a potent vasoconstrictor. Angiotensin I itself is biologically inactive but is converted to angiotensin II by the action of angiotensin-converting enzyme (ACE). The CAS number 82048-97-3 uniquely identifies this specific peptide in chemical databases. In terms of characteristics, angiotensin I is typically soluble in water and exhibits stability under physiological conditions, making it relevant for various research and clinical applications, particularly in studies related to cardiovascular health and hypertension.

<p>H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His (Daprodinam) is a peptide that binds to the response element in the promoter region of the gene encoding for the LDL receptor. Daprodinam inhibits atherosclerosis and has been shown to have an inhibitory effect on angiotensinogen production, which leads to decreased blood pressure. Daprodinam also has inhibitory properties against toll like receptor 4, which is involved in inflammatory bowel disease.</p>

CAS 82048-97-3

angiotensinogen fragment 1-13 human

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-OH

Ref: 3D-FA110931