CAS 82101-18-6

Balsalazide disodium

Description:

Balsalazide disodium is a chemical compound primarily used as a medication for the treatment of ulcerative colitis, a type of inflammatory bowel disease. It is classified as a 5-aminosalicylic acid (5-ASA) derivative, which exerts its therapeutic effects by reducing inflammation in the colon. The compound is a prodrug that is metabolized in the intestines to release the active component, 5-aminosalicylic acid. Balsalazide disodium is typically administered in the form of oral capsules or tablets. Its chemical structure includes a diazo bond, which contributes to its stability and effectiveness in the gastrointestinal tract. The disodium salt form enhances its solubility in water, facilitating absorption and distribution in the body. Common side effects may include gastrointestinal disturbances, headache, and allergic reactions, although it is generally well-tolerated. As with any medication, it is important for patients to follow their healthcare provider's instructions regarding dosage and administration to ensure optimal therapeutic outcomes.

Formula: C₁₇H₁₃N₃Na₂O₆

InChI: InChI=1/C17H15N3O6.2Na/c21-14-5-4-12(9-13(14)17(25)26)20-19-11-3-1-2-10(8-11)16(24)18-7-6-15(22)23;;/h1-5,8-9,21H,6-7H2,(H,18,24)(H,22,23)(H,25,26);;/q;2*+1/p-2

SMILES: c1cc(cc(c1)N=Nc1ccc(c(c1)C(=O)O)O)C(=NCCC(=O)O)O.[Na].[Na]

Synonyms:

• Disodium (3E)-3-[[4-[(3-oxido-3-oxopropyl)carbamoyl]phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate
• disodium (3E)-3-({4-[(2-carboxylatoethyl)carbamoyl]phenyl}hydrazono)-6-oxocyclohexa-1,4-diene-1-carboxylate
• disodium (3Z)-3-({4-[(2-carboxylatoethyl)carbamoyl]phenyl}hydrazono)-6-oxocyclohexa-1,4-diene-1-carboxylate
• disodium 5-[(E)-{4-[(2-carboxylatoethyl)carbamoyl]phenyl}diazenyl]-2-hydroxybenzoate
• [2-Hydroxy-5-[3-[(3-Oxo-3-Sodiooxy-Propyl)Carbamoyl]Phenyl]Azo-Benzoyl]Oxysodium