CAS 82186-77-4

Lumefantrine

Description:

Lumefantrine is an antimalarial compound primarily used in combination with artemether for the treatment of malaria, particularly in areas with chloroquine-resistant strains of Plasmodium falciparum. It is classified as a phenanthrene methanol derivative and exhibits a complex chemical structure that contributes to its pharmacological properties. Lumefantrine is characterized by its lipophilicity, which enhances its absorption and bioavailability when administered orally. The substance has a relatively long half-life, allowing for effective dosing regimens. It works by inhibiting the heme detoxification process in the malaria parasite, leading to the accumulation of toxic heme and ultimately the death of the parasite. Lumefantrine is generally well-tolerated, though it may cause side effects such as gastrointestinal disturbances and, in rare cases, cardiac issues due to its potential to prolong the QT interval. Its efficacy is maximized when used in combination therapies, which help to reduce the risk of resistance development in malaria parasites.

Formula: C₃₀H₃₂Cl₃NO

InChI: InChI=1/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-

InChI key: InChIKey=DYLGFOYVTXJFJP-MYYYXRDXNA-N

SMILES: C(CN(CCCC)CCCC)(O)C1=C2C(/C(=C\C3=CC=C(Cl)C=C3)/C=4C2=CC=C(Cl)C4)=CC(Cl)=C1

Synonyms:

• (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol
• (Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol
• 2-(dibutylamino)-1-{(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl}ethanol
• 2-Dibutylamino-1-[2,7-dichloro-9-[1-(4-chlorophenyl)meth-(Z)-ylidene]-9H-fluoren-4-yl]ethanol
• 9H-Fluorene-4-methanol, 2,7-dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-, (9Z)-
• 9H-Fluorene-4-methanol, 2,7-dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-, (Z)-
• Benflumelol
• Lumefantrine
• dl-Benflumelol
• Benflumetol

Lumefantrine

CAS: 82186-77-4

Formula: C₃₀H₃₂Cl₃NO

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Amber to Dark green powder to crystaline

Molecular weight: 528.94

Ref: 3B-L0256

LUMEFANTRINE RS

CAS: 82186-77-4

LUMEFANTRINE RS

Formula: C₃₀H₃₂Cl₃NO

Molecular weight: 528.9402

Ref: 41-ICRS2125

Lumefantrine

CAS: 82186-77-4

Aromatic drugs of amino-alcohols, other than those contg more than one kind of oxygen function, their ethers and esters; salts thereof, nesoi

Formula: C₃₀H₃₂Cl₃NO

Color and Shape: Yellow Powder

Molecular weight: 527.15495

Ref: 45-1370746

2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol

CAS: 82186-77-4

Formula: C₃₀H₃₂Cl₃NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 528.9402

Ref: IN-DA0036KV

Lumefantrine

CAS: 82186-77-4

Lumefantrine

Purity: 98%

Molecular weight: 528.94g/mol

Ref: 54-OR1030422

Lumefantrine-d9 (Benflumetol-d9)

CAS: 82186-77-4

Formula: C₃₀H₂₃D₉Cl₃NO

Color and Shape: Pale Yellow Solid

Molecular weight: 538.00

Ref: 4Z-L-292

Lumefantrine

CAS: 82186-77-4

Formula: C₃₀H₃₂Cl₃NO

Color and Shape: Yellow Solid

Molecular weight: 528.95

Ref: 4Z-L-291

Lumefantrine

CAS: 82186-77-4

Formula: C₃₀H₃₂Cl₃NO

Purity: ≥ 97.5%

Color and Shape: Light yellow to dark yellow powder

Molecular weight: 528.94

Ref: 7W-GP5101

Lumefantrine

CAS: 82186-77-4

Lumefantrine

Purity: ≥98%

Molecular weight: 528.94g/mol

Ref: 54-BUP15708

Lumefantrine

CAS: 82186-77-4

Formula: C₃₀H₃₂Cl₃NO

Color and Shape: Neat

Molecular weight: 528.94

Ref: 04-C14650030

Lumefantrine

CAS: 82186-77-4

Lumefantrine, an antimalarial, treats malaria with artemether, effective against Plasmodium spp. including in chloroquine-resistant areas.

Formula: C₃₀H₃₂Cl₃NO

Purity: 98.36%

Color and Shape: Yellow Solid

Molecular weight: 528.94

Ref: TM-T3266

Lumefantrine

Controlled Product

CAS: 82186-77-4

Applications Inhibits hemozoin formation. Antimalarial.
References Kumar, N., et al.: Parasitol Res., 76, 214 (1990), Pradines, B., et al.: Antimicrob. Agents Chemother., 43, 418 (1999), Chotivanich, K., et al.: J. Infect. Dis., 182, 629 (2000), Mutabingwa, T., et al.: Lancet, 365, 1474 (2005),

Formula: C₃₀H₃₂Cl₃NO

Color and Shape: Light Yellow

Molecular weight: 528.94

Ref: TR-L474000

Lumefantrine-d9

Controlled Product

CAS: 82186-77-4

Applications Lumefantrine-d9, is the labeled analogue of Lumefantrine (L474000), which Inhibits hemozoin formation, used as Antimalarial.
References Kumar, N., et al.: Parasitol Res., 76, 214 (1990), Pradines, B., et al.: Antimicrob. Agents Chemother., 43, 418 (1999), Chotivanich, K., et al.: J. Infect. Dis., 182, 629 (2000), Mutabingwa, T., et al.: Lancet, 365, 1474 (2005),

Formula: C₃₀H₂₃D₉Cl₃NO

Color and Shape: Neat

Molecular weight: 538.0

Ref: TR-L474003

Lumefantrine

CAS: 82186-77-4

Lumefantrine is an antimalarial compound with action on erythrocytic stages of Plasmodium falciparum by inhibiting β-hematin formation and is used for treating malaria in combination with artemether.

Formula: C₃₀H₃₂Cl₃NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 528.94 g/mol

Ref: 3D-FL24956

Lumefantrine - Bio-X ™

CAS: 82186-77-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₀H₃₂Cl₃NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 528.94 g/mol

Ref: 3D-BL300095

2-(dibutylamino)-1-{2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl}ethan-1-ol

CAS: 82186-77-4

Formula: C₃₀H₃₂Cl₃NO

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 528.94

Ref: 10-F358108

Lumefantrine

CAS: 82186-77-4

Purity: 98%

Molecular weight: 527.15

Ref: 10-F556489