CAS 82354-38-9

Gelsenicine

Description:

Gelsenicine is a naturally occurring alkaloid derived from the plant Gelsemium elegans, known for its potent pharmacological properties. It is classified as a neuromuscular blocking agent and has been studied for its potential therapeutic applications, particularly in pain management and as an anesthetic. The compound exhibits a complex molecular structure, which contributes to its biological activity. Gelsenicine interacts with nicotinic acetylcholine receptors, leading to muscle paralysis, making it of interest in both medical and research settings. Its effects can be dose-dependent, and while it shows promise in certain applications, it also poses risks of toxicity and adverse effects, necessitating careful handling and dosage regulation. The compound's CAS number, 82354-38-9, is a unique identifier that facilitates its recognition in chemical databases and regulatory frameworks. Overall, gelsenicine represents a significant area of study within pharmacology, particularly in the context of neuromuscular interactions and potential therapeutic uses.

Formula: C₁₉H₂₂N₂O₃

InChI: InChI=1S/C19H22N2O3/c1-3-14-11-8-17-19(9-15(20-14)12(11)10-24-17)13-6-4-5-7-16(13)21(23-2)18(19)22/h4-7,11-12,15,17H,3,8-10H2,1-2H3/t11-,12+,15+,17-,19+/m1/s1

InChI key: InChIKey=BIGABVPVCRHEES-NWPJSNQLSA-N

SMILES: O=C1[C@@]2(C=3C(N1OC)=CC=CC3)[C@]4(C[C@@]5([C@@]([C@](C2)(N=C5CC)[H])(CO4)[H])[H])[H]

Synonyms:

• Spiro[3H-indole-3,7′(6′H)-[3,6]methano[3H]oxepino[4,3-b]pyrrol]-2(1H)-one, 2′-ethyl-3′a,4′,8′,8′a-tetrahydro-1-methoxy-, (3S,3′R,3′aS,6′R,8′aS)-
• (3S,3′R,3′aS,6′R,8′aS)-2′-Ethyl-3′a,4′,8′,8′a-tetrahydro-1-methoxyspiro[3H-indole-3,7′(6′H)-[3,6]methano[3H]oxepino[4,3-b]pyrrol]-2(1H)-one
• Gelsedine, 4,20-didehydro-
• Humantenmine
• Spiro[3H-indole-3,7′(6′H)-[3,6]methano[3H]oxepino[4,3-b]pyrrol]-2(1H)-one, 2′-ethyl-3′a,4′,8′,8′a-tetrahydro-9′-hydroxy-1-methoxy-, [3′R-(3′α,3′aβ,6′α,7′α,8′aβ)]-

(3S,3'R,3a'S,6'R,8a'S)-2'-Ethyl-1-methoxy-3a',4',8',8a'-tetrahydro-3'H,6'H-spiro[indoline-3,7'-[3,6]methanooxepino[4,3-b]pyrrol]-2-one

CAS: 82354-38-9

Formula: C₁₉H₂₂N₂O₃

Purity: 98%

Molecular weight: 326.3896

Ref: IN-DA00G67V

Humantenmine

CAS: 82354-38-9

Humantenmine

Purity: ≥98%

Molecular weight: 326.39g/mol

Ref: 54-BUP00391

Gelsenicine

CAS: 82354-38-9

Formula: C₁₉H₂₂N₂O₃

Molecular weight: 326.40

Ref: 7W-GY7095

Gelsenicine

CAS: 82354-38-9

Formula: C₁₉H₂₂N₂O₃

Purity: 95%~99%

Color and Shape: Cryst.

Molecular weight: 326.396

Ref: BP-BP3429

Humantenmine

CAS: 82354-38-9

1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities.

Formula: C₁₉H₂₂N₂O₃

Purity: 99.13% - 99.51%

Color and Shape: Solid

Molecular weight: 326.39

Ref: TM-T2S0663

Gelsenicine

CAS: 82354-38-9

Gelsenicine is a dpp-iv inhibitor that has been shown to be effective in the treatment of bone cancer. Gelsenicine binds to an enzyme called dpp-iv, which inhibits the production of acetylcholine and thus reduces inflammation. It also prevents the production of lc-ms/ms method, which may be due to its ability to inhibit the activity of histone deacetylases and protein kinase C. Gelsenicine has also been found to be active against autoimmune diseases, such as rheumatoid arthritis and psoriasis. This drug is most commonly used in China for treating these conditions.

Formula: C₁₉H₂₂N₂O₃

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 326.39 g/mol

Ref: 3D-FG159082