CymitQuimica logo

CAS 82413-23-8

:

4′-Hydroxytamoxifen

Description:
4′-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM) that is primarily used in the treatment of estrogen receptor-positive breast cancer. It is a derivative of tamoxifen, featuring a hydroxyl group at the para position of the phenyl ring, which enhances its anti-estrogenic activity. This compound exhibits both estrogenic and anti-estrogenic properties, depending on the target tissue, making it a valuable therapeutic agent. Its mechanism of action involves binding to estrogen receptors, thereby inhibiting the proliferation of estrogen-dependent tumors. 4′-Hydroxytamoxifen is characterized by its relatively high lipophilicity, which facilitates its absorption and distribution in the body. Additionally, it has a moderate half-life, allowing for effective dosing regimens. The substance is typically administered orally and is metabolized in the liver, where it may undergo further conversion to other active metabolites. Due to its pharmacological profile, 4′-Hydroxytamoxifen is an important compound in oncology, particularly in the management of breast cancer in postmenopausal women.
Formula:C26H29NO2
InChI:InChI=1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChI key:InChIKey=DODQJNMQWMSYGS-QPLCGJKRSA-N
SMILES:C(=C(/CC)\C1=CC=C(O)C=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3
Synonyms:
  • 4'-Hydroxytamoxifen
  • 4-[(1Z)-1-[[4-[2-(Dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]phenol
  • Phenol,4-[1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-, (Z)-
  • Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 4 products.