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CAS 82436-77-9

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Bis(sulfosuccinimidyl) suberate

Description:
Bis(sulfosuccinimidyl) suberate (BS3) is a crosslinking reagent commonly used in biochemistry and molecular biology for the covalent linkage of proteins and other biomolecules. It is a water-soluble, homobifunctional crosslinker that contains two sulfosuccinimidyl ester groups, which react with primary amines on proteins to form stable amide bonds. BS3 is particularly valued for its ability to facilitate the formation of stable protein complexes without significantly altering the native structure of the proteins involved. The reagent is often utilized in applications such as protein-protein interaction studies, immunoprecipitation, and the stabilization of protein complexes for structural analysis. BS3 is characterized by its relatively short spacer arm, which allows for close proximity between linked molecules, making it suitable for studying interactions that occur at short distances. Additionally, its sulfonate groups enhance solubility in aqueous solutions, making it easier to work with in biological contexts. Proper handling and storage conditions are essential to maintain its reactivity and effectiveness in experimental applications.
Formula:C16H20N2O14S2
InChI:InChI=1S/C16H20N2O14S2/c19-11-7-9(33(25,26)27)15(23)17(11)31-13(21)5-3-1-2-4-6-14(22)32-18-12(20)8-10(16(18)24)34(28,29)30/h9-10H,1-8H2,(H,25,26,27)(H,28,29,30)
InChI key:InChIKey=VYLDEYYOISNGST-UHFFFAOYSA-N
SMILES:O(C(CCCCCCC(ON1C(=O)C(S(=O)(=O)O)CC1=O)=O)=O)N2C(=O)C(S(=O)(=O)O)CC2=O
Synonyms:
  • 1,1'-[(1,8-Dioxooctane-1,8-Diyl)Bis(Oxy)]Bis(2,5-Dioxopyrrolidine-3-Sulfonic Acid)
  • 3-Pyrrolidinesulfonic acid, 1,1′-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis[2,5-dioxo-
  • Bis(sulfosuccinimidyl)-suberate
  • Bs3
  • Di(sulfosuccinimidyl) suberate
  • Octanedioic acid, 1,8-bis(2,5-dioxo-3-sulfo-1-pyrrolidinyl) ester
  • Suberate Bis(sulfosuccinimidyl) Sodium Salt
  • Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester)
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