CAS 82534-75-6

α-Arteether

Description:

α-Arteether is an antimalarial compound derived from artemisinin, which is extracted from the sweet wormwood plant, Artemisia annua. It is primarily used in the treatment of malaria, particularly in cases resistant to conventional therapies. The compound is characterized by its ability to generate reactive oxygen species upon activation in the presence of heme, which leads to the destruction of the malaria parasite. α-Arteether is known for its rapid action and effectiveness against Plasmodium falciparum, the most virulent malaria parasite. It is typically administered via intramuscular injection and is often used in combination with other antimalarial drugs to enhance efficacy and reduce the risk of resistance. The compound is relatively stable under standard conditions but should be stored away from light and moisture to maintain its potency. Its pharmacokinetics involve a quick absorption and distribution in the body, with a relatively short half-life, necessitating careful dosing regimens in clinical settings. Overall, α-Arteether represents a crucial tool in the ongoing fight against malaria.

Formula: C₁₇H₂₈O₅

InChI: InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14-,15-,16-,17-/m1/s1

InChI key: InChIKey=NLYNIRQVMRLPIQ-LTLPSTFDSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@](O[C@H]1OCC)(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]

Synonyms:

• (3R,5aS,6R,8aS,9R,10R,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
• (5aS,6R,8aS,9R,10R,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
• 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10R,12R,12aR)-
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,10β,12β,12aR*)]-
• 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, (5aS,6R,8aS,9R,10R,12R,12aR)-
• α-Arteether