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CAS 82586-55-8

:

Quinapril hydrochloride

Description:
Quinapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is a white to off-white crystalline powder that is soluble in water and exhibits a molecular formula that reflects its complex structure. The substance works by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Quinapril hydrochloride is typically administered orally and is often prescribed in combination with other antihypertensive agents to enhance therapeutic efficacy. Its pharmacokinetics involve rapid absorption, with peak plasma concentrations occurring within a few hours post-administration. The drug is metabolized in the liver to its active form, quinaprilat, which contributes to its antihypertensive effects. Common side effects may include dizziness, fatigue, and cough, while serious adverse effects can involve renal impairment and hyperkalemia. As with any medication, it is essential for patients to consult healthcare professionals for appropriate dosing and monitoring.
Formula:C25H30N2O5·ClH
InChI:InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1
InChI key:InChIKey=IBBLRJGOOANPTQ-JKVLGAQCSA-N
SMILES:C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2[C@H](C(O)=O)CC=3C(C2)=CC=CC3.Cl
Synonyms:
  • (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride (1:1)
  • 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, hydrochloride (1:1), (3S)-
  • 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, monohydrochloride, (3S)-
  • 3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, monohydrochloride, [3S-[2[R*(R*)],3R*]]-
  • Accupril
  • Accuprin
  • Accupro
  • Accupro 20
  • Accupron
  • Acequide
  • See more synonyms
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Found 18 products.