CAS 82626-01-5

Alpidem

Description:

Alpidem, with the CAS number 82626-01-5, is a chemical compound that belongs to the class of drugs known as anxiolytics or sedatives. It is primarily characterized by its ability to modulate the GABA (gamma-aminobutyric acid) receptor, which plays a crucial role in inhibitory neurotransmission in the central nervous system. Alpidem is known for its anxiolytic properties, making it useful in the treatment of anxiety disorders. The compound exhibits a relatively rapid onset of action and a favorable pharmacokinetic profile, which includes a moderate half-life. Its chemical structure features a unique arrangement of functional groups that contribute to its biological activity. While it has shown promise in clinical settings, the use of Alpidem has been limited due to concerns regarding side effects and dependency potential, similar to other benzodiazepine-like medications. As with any pharmaceutical agent, it is essential to consider the therapeutic benefits against potential risks when evaluating its use in clinical practice.

Formula: C₂₁H₂₃Cl₂N₃O

InChI: InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3

InChI key: InChIKey=JRTIDHTUMYMPRU-UHFFFAOYSA-N

SMILES: C(C(N(CCC)CCC)=O)C1=C(N=C2N1C=C(Cl)C=C2)C3=CC=C(Cl)C=C3

Synonyms:

• 2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide
• 6-Chlor-2-(4-chlorphenyl)-N,N-dipropylimidazol(1,2-a)pyridin-3-acetamid
• 6-Chloro-2-(4-chlorophenyl)-N,N-dipropylimidazo[1,2-a]pyridine-3-acetamide
• 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamide
• Alpidem [USAN:INN:BAN]
• Alpidemum
• Alpidemum [Latin]
• Ananxyl
• Imidazo(1,2-a)pyridine-3-acetamide, 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-
• Sl 80.0342-00
• Unii-I93Sc245Qz

Alpidem

CAS: 82626-01-5

Alpidem

Purity: ≥98%

Molecular weight: 404.33g/mol

Ref: 54-BUP12324

Alpidem

CAS: 82626-01-5

Formula: C₂₁H₂₃Cl₂N₃O

Molecular weight: 404.33

Ref: 7W-GP8142

Alpidem

Controlled Product

CAS: 82626-01-5

Applications A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic.
References Min, D., et al.: Pharmacotherapy, 12, 68 (1992), Rothwell, C., et al.: J. Toxicol. Sci., 27, 35 (2002), Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Boelsterli, U., et al.: Curr. Drug Metab., 7, 715 (2006), Rietjens, I., et al.: Chem. Res. Toxicol., 19, 977 (2006),

Formula: C₂₁H₂₃Cl₂N₃O

Color and Shape: Neat

Molecular weight: 404.33

Ref: TR-A575560

Alpidem

Controlled Product

CAS: 82626-01-5

Alpidem is a low-potency short-acting benzodiazepine that is used as a sedative or hypnotic. It is also used for the treatment of insomnia, anxiety disorders, and panic disorder. Alpidem has significant interactions with other drugs such as triazolam, lorazepam and clozapine. It binds to the α1 subunit of the GABAA receptor and increases the activity of gamma-aminobutyric acid (GABA) in the brain by increasing its synthesis and inhibiting its degradation. Alpidem also has been shown to have some anxiolytic effects in animal models.

Formula: C₂₁H₂₃Cl₂N₃O

Purity: Min. 95%

Color and Shape: White To Tan Solid

Molecular weight: 404.33 g/mol

Ref: 3D-FA17325

Alpidem

CAS: 82626-01-5

Alpidem (Ananxyl), a non-sedative imidazopyridine anxiolytic, treats anxiety with high benzodiazepine receptor affinity.

Formula: C₂₁H₂₃Cl₂N₃O

Purity: 99.56% - 99.97%

Color and Shape: White To Off-White Solid

Molecular weight: 404.33

Ref: TM-T26600