CAS 82664-20-8

Flurithromycin

Description:

Flurithromycin is a macrolide antibiotic that is primarily used for its antibacterial properties. It is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, which effectively disrupts the growth of susceptible bacteria. This compound is particularly noted for its activity against various Gram-positive and some Gram-negative bacteria, making it useful in treating respiratory tract infections and other bacterial diseases. Flurithromycin is distinguished by its unique chemical structure, which includes a lactone ring and various functional groups that enhance its pharmacological efficacy and bioavailability. Additionally, it exhibits a favorable pharmacokinetic profile, allowing for effective dosing regimens. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract. As with many antibiotics, the potential for resistance development is a concern, necessitating careful use in clinical settings. Overall, Flurithromycin represents a valuable option in the arsenal of antimicrobial agents, particularly in the treatment of infections caused by specific pathogens.

Formula: C₃₇H₆₆FNO₁₃

InChI: InChI=1S/C37H66FNO13/c1-14-24-37(10,46)29(42)21(5)28(41)34(7,38)17-35(8,45)31(52-33-26(40)23(39(11)12)15-18(2)48-33)19(3)27(20(4)32(44)50-24)51-25-16-36(9,47-13)30(43)22(6)49-25/h18-27,29-31,33,40,42-43,45-46H,14-17H2,1-13H3/t18-,19+,20-,21+,22+,23+,24-,25+,26-,27+,29-,30+,31-,33+,34+,35-,36-,37-/m1/s1

InChI key: InChIKey=XOEUHCONYHZURQ-HNUBZJOYSA-N

SMILES: O([C@H]1[C@H](C)[C@@H](O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)[C@H]3C[C@](OC)(C)[C@@H](O)[C@H](C)O3

Synonyms:

• (3R,4S,5S,6R,7R,9S,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-9-fluoro-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name)
• (8S)-8-Fluoroerythromycin
• (8S)-8-Fluoroerythromycin A
• 8-Fluoroerythromycin
• 8-Fluoroerythromycin A
• Antibiotic P 80206
• Cl-932
• Erythromycin, 8-fluoro-
• Flurithromycin [INN]
• Flurithromycine
• Flurithromycine [French]
• Fluritromicina
• Fluritromicina [Spanish]
• Fluritromycinum
• Fluritromycinum [Latin]
• Oxacyclotetradecane, erythromycin deriv.
• P 80206
• P-0501A

Flurithromycin

CAS: 82664-20-8

Flurithromycin is an orally active, broad-spectrum antibiotic for bacterial infection research.

Formula: C₃₇H₆₆FNO₁₃

Color and Shape: Solid

Molecular weight: 751.92

Ref: TM-T73670

8-Fluoro Erythromycin

Controlled Product

CAS: 82664-20-8

Applications A fluorinated derivative of Erythromycin (E649950). A macrolide antibiotic.
References Labro, M. et al.: Macrolide Antibiot., 37 (2002); Lo Bue, A.M. et al.: J. Chemother., 13, 255 (2001); Fera, M.T. et al.: Int. J. Antimicrob. Agents, 17, 151 (2001);

Formula: C₃₇H₆₆FNO₁₃

Color and Shape: Off-White

Molecular weight: 751.92

Ref: TR-F591585

8-Fluoro erythromycin

CAS: 82664-20-8

8-Fluoro erythromycin is a synthetic derivative of the macrolide antibiotic erythromycin. It is derived from the fermentation of *Streptomyces erythraeus*, a species known for producing erythromycin, which is chemically modified to include a fluorine atom at the eighth position. This modification enhances its pharmacokinetic properties, improving its stability and bioavailability compared to the parent compound.

Formula: C₃₇H₆₆FNO₁₃

Purity: Min. 95%

Molecular weight: 751.92 g/mol

Ref: 3D-AF16726