CAS 827022-33-3

PD0332991 Isethionate

Description:

PD0332991 Isethionate, also known as Palbociclib, is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which play a crucial role in cell cycle regulation. This compound is primarily utilized in the treatment of hormone receptor-positive breast cancer, particularly in combination with aromatase inhibitors or estrogen receptor antagonists. PD0332991 is characterized by its ability to inhibit tumor cell proliferation by preventing the transition from the G1 phase to the S phase of the cell cycle, thereby impeding cancer cell growth. The isethionate salt form enhances its solubility and bioavailability, making it suitable for oral administration. In terms of its chemical structure, PD0332991 features a complex arrangement of aromatic rings and functional groups that contribute to its pharmacological activity. The compound has undergone extensive clinical trials, demonstrating efficacy in various patient populations, and is recognized for its relatively favorable safety profile compared to traditional chemotherapeutics. Overall, PD0332991 Isethionate represents a significant advancement in targeted cancer therapy.

Formula: C₂₄H₂₉N₇O₂·C₂H₆O₄S

Synonyms:

• Palbociclib isethionate
• Palbociclib (PD0332991) Isethionate
• PD 0332991-0054
• PD0332991 Isethiote
• PF 00080665-73
• palbociclib Isethionate 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one mono-isethionate salt
• Ethanesulfonic acid, 2-hydroxy-, compd. with 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one (1:1)
• PD0332991 Isethionate

Palbociclib isethionate

CAS: 827022-33-3

Formula: C₂₆H₃₅N₇O₆S

Purity: 99%

Color and Shape: Solid

Molecular weight: 573.6644

Ref: IN-DA00390W

Palbociclib Isethionate

CAS: 827022-33-3

Palbociclib Isethionate

Purity: ≥98%

Molecular weight: 573.66g/mol

Ref: 54-BUP14482

Palbociclib isethionate

CAS: 827022-33-3

Formula: C₂₆H₃₅N₇O₆S

Purity: ≥ 98.0%

Color and Shape: White to beige powder

Molecular weight: 573.66

Ref: 7W-GP9190

Palbociclib isethionate

CAS: 827022-33-3

Palbociclib isethionate

Purity: 99%

Molecular weight: 573.66g/mol

Ref: 54-OR1025469

Palbociclib Isethionate

CAS: 827022-33-3

Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。

Formula: C₂₄H₂₉N₇O₂·C₂H₆O₄S

Purity: 99.01% - 99.27%

Color and Shape: Solid

Molecular weight: 573.66

Ref: TM-T6240

Palbociclib isethionate

CAS: 827022-33-3

Purity: 99%

Color and Shape: Solid

Molecular weight: 573.6699829

Ref: 10-F794407

PD 0332991 Isethionate

CAS: 827022-33-3

Selective and potent inhibitor of cyclin-dependent kinases CDK4 and CDK6. It blocks cell cycle progression from phase G1 into S by inhibiting CDK4/6-dependent retinoblastoma (RB) phosphorylation. It has been used for the treatment of HER2 negative, estrogen receptor (ER) positive metastatic breast cancer.

Formula: C₂₄H₂₉N₇O₂·C₂H₆O₄S

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 573.67 g/mol

Ref: 3D-FP137710