CAS 82752-99-6
:Nefazodone hydrochloride
Description:
Nefazodone hydrochloride is a pharmaceutical compound primarily used as an antidepressant. It belongs to the class of drugs known as serotonin receptor antagonists and reuptake inhibitors (SARIs). The chemical structure of nefazodone features a complex arrangement that includes a phenylpiperazine moiety, contributing to its pharmacological activity. As a hydrochloride salt, it is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits moderate stability under standard conditions. Nefazodone acts by modulating serotonin levels in the brain, thereby alleviating symptoms of depression and anxiety. It is known for its relatively favorable side effect profile compared to other antidepressants, although it can still cause drowsiness, dizziness, and potential liver toxicity in some patients. Due to its unique mechanism of action, nefazodone is sometimes prescribed when other antidepressants are ineffective or poorly tolerated. However, its use has declined in recent years, partly due to concerns about liver safety and the availability of newer antidepressants with improved safety profiles.
Formula:C25H32ClN5O2·ClH
InChI:InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
InChI key:InChIKey=DYCKFEBIOUQECE-UHFFFAOYSA-N
SMILES:C(COC1=CC=CC=C1)N2C(CC)=NN(CCCN3CCN(CC3)C4=CC(Cl)=CC=C4)C2=O.Cl
Synonyms:- 1-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride
- 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride (1:1)
- 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, hydrochloride (1:1)
- 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
- Bmy 13754
- Bmy 13754-1
- Dutonin
- Mj 13754-1
- Nefazodone Hydrochloride
- Serazone
- Serzone
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Found 17 products.
Nefazodone hydrochloride, 98+%
CAS:<p>An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy b</p>Formula:C25H32ClN5O2•HClPurity:98+%Molecular weight:506.47Nefazodone Hydrochloride
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C25H32ClN5O2·HClColor and Shape:White PowderMolecular weight:469.224451-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride
CAS:Formula:C25H33Cl2N5O2Purity:98%Color and Shape:SolidMolecular weight:506.4678Nefazodone HCl
CAS:Formula:C25H32ClN5O2·HClColor and Shape:White To Off-White SolidMolecular weight:506.48Nefazodone Hydrochloride
CAS:Controlled ProductFormula:C25H32ClN5O2·ClHColor and Shape:NeatMolecular weight:506.47Nefazodone hydrochloride
CAS:<p>Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.</p>Formula:C25H33Cl2N5O2Purity:99% - 99.86%Color and Shape:White SolidMolecular weight:506.47Nefazodone Hydrochloride
CAS:Controlled Product<p>Applications A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.<br>References Eison, A.S., et al.: Psychopharmacol. Bull., 26, 311 (1990), Keller, M.B., et al.: N. Engl. J. Med., 342, 1462 (2000);<br></p>Formula:C25H32ClN5O2·ClHColor and Shape:NeatMolecular weight:506.47Nefazodone HCl - Bio-X ™
CAS:Controlled Product<p>Nefazodone is an anti-depressant that belongs to the group of drugs called selective serotonin reuptake inhibitors (SSRIs) and is used for the treatment of depression. Nefazodone binds to 5-HT2a receptors, which are in the central nervous system, and inhibit the release of neurotransmitters such as dopamine, norepinephrine, and serotonin. As a result, this leads to an increase in levels of these neurotransmitters in the brain. Nefazodone has also been shown to have beneficial effects on brain functions such as memory retrieval and mood control.</p>Formula:C25H33Cl2N5O2Purity:Min. 95%Color and Shape:PowderMolecular weight:506.47 g/molNefazodone Hydrochloride
CAS:Formula:C25H32ClN5O2·HClPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:506.47Nefazodone-d6 Dihydrochloride
CAS:Controlled Product<p>Applications Labelled Nefazodone (N389100). A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.<br>References Eison, A.S., et al.: Psychopharmacol. Bull., 26, 311 (1990), Keller, M.B., et al.: N. Engl. J. Med., 342, 1462 (2000)<br></p>Formula:C25H26D6ClN5O2·2HClColor and Shape:NeatMolecular weight:476.0523646Nefazodone hydrochloride
CAS:Controlled Product<p>Antagonist of 5-HT2A serotonin, α2-adrenergic and dopamine (D2) receptors</p>Formula:C25H33Cl2N5O2Purity:Min. 95%Color and Shape:PowderMolecular weight:506.47 g/mol
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