CAS 82752-99-6

Nefazodone hydrochloride

Description:

Nefazodone hydrochloride is a pharmaceutical compound primarily used as an antidepressant. It belongs to the class of drugs known as serotonin receptor antagonists and reuptake inhibitors (SARIs). The chemical structure of nefazodone features a complex arrangement that includes a phenylpiperazine moiety, contributing to its pharmacological activity. As a hydrochloride salt, it is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits moderate stability under standard conditions. Nefazodone acts by modulating serotonin levels in the brain, thereby alleviating symptoms of depression and anxiety. It is known for its relatively favorable side effect profile compared to other antidepressants, although it can still cause drowsiness, dizziness, and potential liver toxicity in some patients. Due to its unique mechanism of action, nefazodone is sometimes prescribed when other antidepressants are ineffective or poorly tolerated. However, its use has declined in recent years, partly due to concerns about liver safety and the availability of newer antidepressants with improved safety profiles.

Formula: C₂₅H₃₂ClN₅O₂·ClH

InChI: InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI key: InChIKey=DYCKFEBIOUQECE-UHFFFAOYSA-N

SMILES: C(COC1=CC=CC=C1)N2C(CC)=NN(CCCN3CCN(CC3)C4=CC(Cl)=CC=C4)C2=O.Cl

Synonyms:

• 1-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride
• 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride (1:1)
• 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, hydrochloride (1:1)
• 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
• Bmy 13754
• Bmy 13754-1
• Dutonin
• Mj 13754-1
• Nefazodone Hydrochloride
• Serazone
• Serzone

Nefazodone hydrochloride, 98+%

CAS: 82752-99-6

An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy b

Formula: C₂₅H₃₂ClN₅O₂•HCl

Purity: 98+%

Molecular weight: 506.47

Ref: 02-J62793

Nefazodone Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 82752-99-6

Color and Shape: Single Solution

Ref: 61-AMP0591.00-01

Nefazodone Hydrochloride

CAS: 82752-99-6

Color and Shape: Neat

Ref: 61-FOR0591.00

Nefazodone Hydrochloride

CAS: 82752-99-6

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₅H₃₂ClN₅O₂·HCl

Color and Shape: White Powder

Molecular weight: 469.22445

Ref: 45-1457902

1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride

CAS: 82752-99-6

Formula: C₂₅H₃₃Cl₂N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 506.4678

Ref: IN-DA00582N

Nefazodone hydrochloride

CAS: 82752-99-6

Formula: C₂₅H₃₂ClN₅O₂HCl

Molecular weight: 506.47

Ref: 7W-GP2852

Nefazodone HCl

CAS: 82752-99-6

Formula: C₂₅H₃₂ClN₅O₂·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 506.48

Ref: 4Z-N-031

Nefazodone hydrochloride

CAS: 82752-99-6

Nefazodone hydrochloride

Purity: ≥98%

Molecular weight: 506.47g/mol

Ref: 54-BUP13482

Nefazodone Hydrochloride

CAS: 82752-99-6

Nefazodone Hydrochloride

Purity: >98.0%

Molecular weight: 506.47g/mol

Ref: 54-OR1023368

Nefazodone Hydrochloride

Controlled Product

CAS: 82752-99-6

Formula: C₂₅H₃₂ClN₅O₂·ClH

Color and Shape: Neat

Molecular weight: 506.47

Ref: 86-MM0591.00

Nefazodone-d5 HCl

CAS: 82752-99-6

Formula: C₂₅H₂₇D₅ClN₅O₂·HCl

Molecular weight: 511.51

Ref: 4Z-N-032

Nefazodone hydrochloride

CAS: 82752-99-6

Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.

Formula: C₂₅H₃₃Cl₂N₅O₂

Purity: 99% - 99.86%

Color and Shape: White Solid

Molecular weight: 506.47

Ref: TM-T3275

Nefazodone Hydrochloride

Controlled Product

CAS: 82752-99-6

Applications A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
References Eison, A.S., et al.: Psychopharmacol. Bull., 26, 311 (1990), Keller, M.B., et al.: N. Engl. J. Med., 342, 1462 (2000);

Formula: C₂₅H₃₂ClN₅O₂·ClH

Color and Shape: Neat

Molecular weight: 506.47

Ref: TR-N389100

Nefazodone-d6 Dihydrochloride

Controlled Product

CAS: 1330236-06-0, 82752-99-6

Applications Labelled Nefazodone (N389100). A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
References Eison, A.S., et al.: Psychopharmacol. Bull., 26, 311 (1990), Keller, M.B., et al.: N. Engl. J. Med., 342, 1462 (2000)

Formula: C₂₅H₂₆D₆ClN₅O₂·2HCl

Color and Shape: Neat

Molecular weight: 476.0523646

Ref: TR-N389102

Nefazodone HCl - Bio-X ™

Controlled Product

CAS: 82752-99-6

Nefazodone is an anti-depressant that belongs to the group of drugs called selective serotonin reuptake inhibitors (SSRIs) and is used for the treatment of depression. Nefazodone binds to 5-HT2a receptors, which are in the central nervous system, and inhibit the release of neurotransmitters such as dopamine, norepinephrine, and serotonin. As a result, this leads to an increase in levels of these neurotransmitters in the brain. Nefazodone has also been shown to have beneficial effects on brain functions such as memory retrieval and mood control.

Formula: C₂₅H₃₃Cl₂N₅O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 506.47 g/mol

Ref: 3D-BN164641

Nefazodone Hydrochloride

CAS: 82752-99-6, 83366-66-9

Formula: C₂₅H₃₂ClN₅O₂·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 506.47

Ref: 3B-N1030

Nefazodone hydrochloride

Controlled Product

CAS: 82752-99-6

Antagonist of 5-HT2A serotonin, α2-adrenergic and dopamine (D2) receptors

Formula: C₂₅H₃₃Cl₂N₅O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 506.47 g/mol

Ref: 3D-FN26173