CAS 82768-85-2
:Quinaprilat
Description:
Quinaprilat is the active metabolite of quinapril, an angiotensin-converting enzyme (ACE) inhibitor used primarily in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Quinaprilat is a white to off-white crystalline powder that is soluble in water and exhibits a pKa indicating its acidic nature. Its molecular structure includes a carboxyl group, which is crucial for its biological activity. The compound has a relatively long half-life, allowing for once-daily dosing in clinical settings. Quinaprilat is typically administered orally and is known for its efficacy in managing cardiovascular conditions. As with other ACE inhibitors, it may have side effects such as cough, hyperkalemia, and hypotension, and it is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy. Overall, quinaprilat plays a significant role in cardiovascular pharmacotherapy.
Formula:C23H26N2O5
InChI:InChI=1S/C23H26N2O5/c1-15(24-19(22(27)28)12-11-16-7-3-2-4-8-16)21(26)25-14-18-10-6-5-9-17(18)13-20(25)23(29)30/h2-10,15,19-20,24H,11-14H2,1H3,(H,27,28)(H,29,30)/t15-,19-,20-/m0/s1
InChI key:InChIKey=FLSLEGPOVLMJMN-YSSFQJQWSA-N
SMILES:C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2[C@H](C(O)=O)CC=3C(C2)=CC=CC3
Synonyms:- (3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
- 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, (3S)-
- 3-Isoquinolinecarboxylic acid, 2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, [3S-[2[R*(R*)],3R*]]-
- 3-Isoquinolinecarboxylicacid, 2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-1,2,3,4-tetrahydro-,[3S-[2[R*(R*)],3R*]]-
- Ci 928
- Quinaprilat
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Found 8 products.
Quinapril Related Compound B (3-Isoquinolinecarboxylic acid, 2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-1,2,3,4-tetrahydro-,[3S-[2[R*(R*)],3R*]])
CAS:Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fusedFormula:C23H26N2O5Color and Shape:White PowderMolecular weight:410.18417Quinapril EP Impurity C (Quinapril USP Related Compound B, Quinaprilat)
CAS:Formula:C23H26N2O5Color and Shape:White To Off-White SolidMolecular weight:410.47Quinaprilat
CAS:<p>Quinaprilat is a prodrug that is metabolized to its active form, quinapril. It is used to treat heart disease, including congestive heart failure. Quinaprilat binds to the papillary muscle and prevents the contraction of this muscle, which causes an increase in blood pressure. Quinaprilat also has an anti-inflammatory effect, which may be due to its ability to inhibit PCSK9 production.</p>Formula:C23H26N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:410.46 g/molQuinaprilat
CAS:<p>Quinaprilat inhibits angiotensin converting enzyme.</p>Formula:C23H26N2O5Purity:98%Color and Shape:Crystalline SolidMolecular weight:410.46
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