CAS 82824-01-9
:Naloxonazine
Description:
Naloxonazine is a synthetic opioid derivative primarily known for its role as a selective antagonist of the mu-opioid receptor. It is characterized by its ability to block the effects of opioids, making it a potential candidate for research in opioid addiction and overdose treatment. The compound has a complex chemical structure that includes a phenolic hydroxyl group and a piperidine ring, contributing to its pharmacological properties. Naloxonazine exhibits a high affinity for the mu-opioid receptor, which is crucial for its antagonistic effects. Unlike traditional opioids, it does not produce significant analgesic effects, making it less likely to be abused. Its pharmacokinetics involve metabolism primarily in the liver, and it is excreted through urine. Research into naloxonazine has focused on its potential therapeutic applications, particularly in mitigating the effects of opioid overdose and in the treatment of opioid use disorder. However, further studies are necessary to fully understand its efficacy and safety profile in clinical settings.
Formula:C38H42N4O6
InChI:InChI=1/C38H42N4O6/c1-3-15-41-17-13-35-29-21-5-7-25(43)31(29)47-33(35)23(9-11-37(35,45)27(41)19-21)39-40-24-10-12-38(46)28-20-22-6-8-26(44)32-30(22)36(38,34(24)48-32)14-18-42(28)16-4-2/h3-8,27-28,33-34,43-46H,1-2,9-20H2/b39-23-,40-24-
InChI key:InChIKey=AJPSBXJNFJCCBI-ZJKKPOQTSA-N
SMILES:O[C@]12[C@@]34C=5C(O[C@]3(C(=NN=C6[C@]7([C@]89C=%10C(O7)=C(O)C=CC%10C[C@]([C@]8(O)CC6)(N(CC=C)CC9)[H])[H])CC1)[H])=C(O)C=CC5C[C@]2(N(CC=C)CC4)[H]
Synonyms:- NIH 10894
- Naloxonazine
- NSC 612113
- Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, 2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-ylidene]hydrazone
- Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, [(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone, (5α)-
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Naloxonazine
CAS:<p>Naloxonazine, a potent, selective opiate mu-1 (μ1) antagonist, also influences leishmania through the modulation of host coding function.</p>Formula:C38H42N4O6Color and Shape:SolidMolecular weight:650.76
