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CAS 82952-64-5

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Trimetrexate glucuronate

Description:
Trimetrexate glucuronate is a chemical compound that serves as an active metabolite of trimetrexate, a folate antagonist primarily used in the treatment of certain types of cancer and infections, particularly those caused by Pneumocystis jirovecii. This compound is characterized by its ability to inhibit dihydrofolate reductase, an enzyme critical for DNA synthesis and cell proliferation. Trimetrexate glucuronate is typically administered in a clinical setting and is known for its enhanced solubility compared to its parent compound, which can improve its bioavailability. The glucuronate moiety contributes to its pharmacokinetic properties, facilitating its excretion and potentially reducing toxicity. As a derivative, it retains the core structure of trimetrexate while exhibiting modified interactions with biological systems. Its therapeutic applications are often explored in combination with other agents to enhance efficacy and minimize resistance. Overall, trimetrexate glucuronate exemplifies the importance of chemical modifications in optimizing drug performance in oncology and infectious disease treatment.
Formula:C25H33N5O10
InChI:InChI=1/C19H23N5O3.C6H10O7/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3;7-1-2(8)3(9)4(10)5(11)6(12)13/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24);1-5,8-11H,(H,12,13)/t;2-,3+,4-,5-/m.0/s1
InChI key:InChIKey=ZCJXQWYMBJYJNB-LRDBBFHQSA-N
SMILES:CC=1C2=C(C=CC1CNC3=CC(OC)=C(OC)C(OC)=C3)N=C(N)N=C2N.[C@H]([C@@H]([C@H](C=O)O)O)([C@@H](C(O)=O)O)O
Synonyms:
  • 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-, mono-<span class="text-smallcaps">D</span>-glucuronate
  • 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine D-glucuronate
  • 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine - D-glucuronic acid (1:1)
  • <span class="text-smallcaps">D</span>-Glucuronic acid, compd. with 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine (1:1)
  • Neutrexin
  • 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-, mono-D-glucuronate
  • Trimetrexate glucuronate
  • D-Glucuronic acid, compd. with 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine (1:1)
  • 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride
  • CI 898 D-Glucuronic Acid Salt (Trimetrexate D-Glucuronic Acid Salt)
  • See more synonyms
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