CAS 82964-04-3

Tolrestat

Description:

Tolrestat is a chemical compound primarily recognized for its role as an aldose reductase inhibitor, which is significant in the management of diabetic complications. It is characterized by its ability to inhibit the enzyme aldose reductase, thereby reducing the conversion of glucose to sorbitol, a process implicated in diabetic neuropathy and retinopathy. The molecular structure of Tolrestat includes a specific arrangement of functional groups that contribute to its biological activity. It is typically administered in a pharmaceutical context, and its efficacy has been studied in various clinical settings. The compound is known for its moderate solubility in organic solvents and limited solubility in water, which can influence its bioavailability and pharmacokinetics. Safety and toxicity profiles are essential considerations in its use, as with any therapeutic agent. Overall, Tolrestat represents a significant focus in research aimed at alleviating the complications associated with diabetes through targeted enzymatic inhibition.

Formula: C₁₆H₁₄F₃NO₃S

InChI: InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)

InChI key: InChIKey=LUBHDINQXIHVLS-UHFFFAOYSA-N

SMILES: C(N(CC(O)=O)C)(=S)C=1C2=C(C(C(F)(F)F)=C(OC)C=C2)C=CC1

Synonyms:

• 2-(6-Methoxy-N-methyl-5-(trifluoromethyl)naphthalene-1-carbothioamido)aceticacid
• Alredase
• Ay 27773
• Glycine, N-((6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)thioxomethyl)-N-methyl-
• Lorestat
• N-(6-Methoxythio-5-(trifluoromethyl)-1-naphthoyl)sarcosine
• N-[[6-Methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine
• N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]carbothioyl}-N-methylglycine
• Tolrestat [USAN:INN:BAN]
• Tolrestatin
• Tolrestatum
• Tolrestatum [Latin]

Tolrestat

CAS: 82964-04-3

Formula: C₁₆H₁₄F₃NO₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 357.3475

Ref: IN-DA00G3QA

Tolrestat

CAS: 82964-04-3

Formula: C₁₆H₁₄F₃NO₃S

Molecular weight: 357.35

Ref: 7W-GP1159

Tolrestat

CAS: 82964-04-3

Tolrestat

Purity: ≥98%

Molecular weight: 357.35g/mol

Ref: 54-BUP16308

Tolrestat

Controlled Product

CAS: 82964-04-3

Applications Tolrestat is an aldose reductase inhibitor.
References Fortes, Z.B., et. al.: Gen. Pharmacol., 27, 917 (1996)

Formula: C₁₆H₁₄F₃NO₃S

Color and Shape: Neat

Molecular weight: 357.35

Ref: TR-T535490

Tolrestat

CAS: 82964-04-3

Aldose reductase AKR1B10 inhibitor; hepatotoxic

Formula: C₁₆H₁₄F₃NO₃S

Purity: Min. 95%

Molecular weight: 357.35 g/mol

Ref: 3D-FT63881

TOLRESTAT

CAS: 82964-04-3

Purity: 98%

Molecular weight: 357.3500061

Ref: 10-F827170

Tolrestat-d3

Controlled Product

CAS: 82964-04-3

Formula: C₁₆H₁₁D₃F₃NO₃S

Color and Shape: Neat

Molecular weight: 360.37

Ref: TR-T535492

Tolrestat

CAS: 82964-04-3

Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).

Formula: C₁₆H₁₄F₃NO₃S

Purity: 98.89% - >99.99%

Color and Shape: Solid

Molecular weight: 357.35

Ref: TM-T17114