CAS 83-74-9

(-)-Ibogaine

Description:

(-)-Ibogaine is a naturally occurring alkaloid derived from the root bark of the Tabernanthe iboga plant, primarily found in Central Africa. It is classified as a psychoactive compound and is known for its complex pharmacological profile, which includes interactions with various neurotransmitter systems, particularly the serotonin and dopamine receptors. (-)-Ibogaine has garnered attention for its potential therapeutic effects, particularly in the treatment of substance use disorders, as it may help alleviate withdrawal symptoms and reduce cravings. The compound exhibits a chiral structure, with the "(-)" designation indicating its specific enantiomeric form, which is associated with its psychoactive properties. In terms of physical characteristics, (-)-Ibogaine is typically a white to off-white crystalline solid. Its solubility varies in different solvents, and it is often administered in a controlled setting due to its potent effects and the potential for adverse reactions. Research into (-)-Ibogaine continues, focusing on its safety, efficacy, and mechanisms of action in the context of addiction treatment and other therapeutic applications.

Formula: C₂₀H₂₆N₂O

InChI: InChI=1S/C20H26N2O/c1-3-13-8-12-9-17-19-15(6-7-22(11-12)20(13)17)16-10-14(23-2)4-5-18(16)21-19/h4-5,10,12-13,17,20-21H,3,6-9,11H2,1-2H3/t12-,13+,17+,20+/m1/s1

InChI key: InChIKey=HSIBGVUMFOSJPD-CFDPKNGZSA-N

SMILES: C(C)[C@@H]1[C@]2([C@@]3(C4=C(C=5C(N4)=CC=C(OC)C5)CC[N@]2C[C@@](C3)(C1)[H])[H])[H]

Synonyms:

• 6,9-Methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole, ibogamine deriv.
• 7-Ethyl-6,6beta,7,8,9,10,12,13-octahydro-2-methoxy-6,9-methano-5H-pyrido(1',2':1,2)azepino(5,4-b)indole
• DEA No. 7260
• Endabuse
• Ibogain
• Ibogaine
• Ibogaine (8CI)
• Ibogamine, 12-methoxy-
• Nih 10567
• Nsc 249764
• Tabernanthe iboga
• Unii-3S814I130U
• 12-Methoxyibogamine

Ibogaine

CAS: 83-74-9

Formula: C₂₀H₂₆N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 310.44

Ref: 4Z-I-357

Ibogaine-13C-d3

CAS: 83-74-9

Formula: C₁₉₁₃CH₂₃D₃N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 314.45

Ref: 4Z-I-352

Ibogaine

Controlled Product

CAS: 83-74-9

Ibogaine is a psychoactive substance, which is an indole alkaloid derived from the root bark of the Tabernanthe iboga plant. This plant is native to Central Africa and has been traditionally used in spiritual and healing ceremonies by indigenous communities. Ibogaine acts primarily as a serotonergic and dopaminergic system modulator, exhibiting complex interactions at several neurotransmitter systems, including NMDA receptors and sigma-2 receptors, and functioning as an antagonist at the α3β4 nicotinic acetylcholine receptors.Current research focuses on its potential applications in interrupting substance addiction cycles, particularly for opioids and stimulants, by reducing withdrawal symptoms and cravings. Its ability to induce an altered state of consciousness is also being studied in the context of psychotherapy. However, the administration of Ibogaine requires careful clinical oversight due to its potent psychoactive effects and potential cardiac risks. Preclinical and clinical studies continue to investigate its efficacy and safety profile, with a focus on understanding the neurobiological mechanisms underlying its therapeutic benefits.

Formula: C₂₀H₂₆N₂O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 310.43 g/mol

Ref: 3D-FI159190