CAS 83166-18-1

Tampramine fumarate

Description:

Tampramine fumarate, with the CAS number 83166-18-1, is a chemical compound that belongs to the class of antidepressants. It is primarily characterized by its dual action as a serotonin and norepinephrine reuptake inhibitor (SNRI), which makes it effective in treating mood disorders. The fumarate salt form enhances its solubility and stability, facilitating its use in pharmaceutical formulations. Tampramine is known for its ability to modulate neurotransmitter levels in the brain, contributing to its therapeutic effects. The compound typically exhibits a moderate to high bioavailability, and its pharmacokinetics can be influenced by various factors, including dosage and individual metabolism. Additionally, like many psychotropic medications, it may have a range of side effects, which can vary among individuals. Overall, Tampramine fumarate represents a significant option in the pharmacological management of depression and anxiety disorders, although its use should be guided by a healthcare professional to ensure safety and efficacy.

Formula: C₂₃H₂₄N₄·C₄H₄O₄

InChI: InChI=1S/C23H24N4.C4H4O4/c1-26(2)16-9-17-27-21-14-7-6-12-19(21)22(18-10-4-3-5-11-18)25-20-13-8-15-24-23(20)27;5-3(6)1-2-4(7)8/h3-8,10-15H,9,16-17H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=USQAILMOWHOBTK-WLHGVMLRSA-N

SMILES: C(CCN(C)C)N1C=2C(C(=NC=3C1=NC=CC3)C4=CC=CC=C4)=CC=CC2.C(=C/C(O)=O)\C(O)=O

Synonyms:

• Tampramine fumarate
• 11H-Pyrido[2,3-b][1,4]benzodiazepine-11-propanamine, N,N-dimethyl-6-phenyl-, (2E)-2-butenedioate (1:1)
• 11H-Pyrido[2,3-b][1,4]benzodiazepine-11-propanamine, N,N-dimethyl-6-phenyl-, (E)-2-butenedioate (1:1)
• AHR 9377

Tampramine fumarate

CAS: 83166-18-1

Tampramine is a ligand for the nicotinic acetylcholine receptor. It has been used as a research tool to study the function of ion channels, and as a pharmacological agent for the treatment of epilepsy. Tampramine binds to the nicotinic acetylcholine receptor and blocks its activation by acetylcholine or nicotine. Tampramine also inhibits the binding of other ligands, such as atropine, to their receptors. Tampramine is an inhibitor of phosphodiesterase (PDE) enzymes which are involved in signal transduction pathways that regulate cellular processes including cell proliferation, differentiation and apoptosis. PDEs hydrolyze cyclic nucleotides, such as cAMP and cGMP, which are important second messengers in intracellular signaling cascades.

Formula: C₂₇H₂₈N₄O₄

Purity: Min. 95%

Molecular weight: 472.5 g/mol

Ref: 3D-IDA16618