CAS 832747-55-4

Risperidone N-Oxide

Description:

Risperidone N-Oxide is a chemical compound derived from risperidone, an atypical antipsychotic medication primarily used to treat schizophrenia and bipolar disorder. The N-oxide form indicates that the nitrogen atom in the piperidine ring of risperidone has been oxidized, which can influence its pharmacological properties and metabolic pathways. This compound is characterized by its molecular structure, which includes a piperidine ring, a benzisoxazole moiety, and an N-oxide functional group. Risperidone N-Oxide may exhibit altered binding affinities to neurotransmitter receptors compared to its parent compound, potentially affecting its efficacy and side effect profile. It is important to note that while risperidone is well-studied, the specific pharmacological effects and clinical significance of risperidone N-Oxide are less understood and may require further research. As with many pharmaceutical compounds, safety, efficacy, and regulatory status would be determined through rigorous clinical studies and evaluations.

Formula: C₂₃H₂₇FN₄O₃

Synonyms:

• Cis-Risperidone N-Oxide
• Risperidone N-Oxide
• trans-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, N-oxide monohydrate
• Risperidone trans-N-oxide (trans-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one, N-oxide Monohydrate)
• Risperidone Impurity N-Oxide
• 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-oxido-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-
• Risperidone trans-N-oxide
• 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-oxido-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• Risperidone N-Oxide ISO 9001：2015 REACH
• Risperidone Impurity1287
• cis-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, N-oxide monohydrate
• 4-(6-Fluorobenzo[d]isoxazol-3-yl)-1-(2-(2-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyriMidin-3-yl)ethyl)piperidine 1-oxide
• Risperidone trans-N-oxide (cis-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one, N-oxide Monohydrate)
• Risperidone N-oxide IMpurity
• Risperidone cis-N-oxide
• Risperidone impurity 11/Risperidone N-Oxide/3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-oxido-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Risperidone N-Oxide (Mixture of cis and trans Isomers)

CAS: 832747-55-4

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: Off-White Solid

Molecular weight: 426.49

Ref: 4Z-R-0620

Risperidone N-oxide

CAS: 832747-55-4

Formula: C₂₃H₂₇FN₄O₃

Molecular weight: 426.49

Ref: ST-EA-CP-R15015

Risperidone N-Oxide

Controlled Product

CAS: 832747-55-4

Applications Risperidone (R525000) impurity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References El-Sherif, Z., et al.: J. Pharm. Biomed. Anal., 36, 975 (2005), Sattanathan, P., et al.: J. Pharm. Biomed. Anal., 40, 598 (2006),

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: White

Molecular weight: 426.48

Ref: TR-R525010

Risperidone N-oxide

CAS: 832747-55-4

Risperidone N-oxide is a prodrug of risperidone. It is prepared by reacting risperidone with methanol and hydrogen peroxide in the presence of piperidine, followed by purification using preparative high-performance liquid chromatography. Risperidone N-oxide is a crystalline solid with a melting point of about 190 °C. Risperidone N-oxide has been shown to have antiemetic properties, which may be due to its ability to block dopamine receptors in the brain. The drug also shows some antipsychotic activity, and it has a constant therapeutic effect against schizophrenia. The major impurities found in risperidone N-oxide are hydroxylamine and piperidine.

Formula: C₂₃H₂₇FN₄O₃

Purity: Min. 95%

Molecular weight: 426.48 g/mol

Ref: 3D-IR27739