CAS 83366-66-9

Nefazodone

Description:

Nefazodone is an antidepressant medication primarily used to treat major depressive disorder. It belongs to the class of drugs known as serotonin antagonist and reuptake inhibitors (SARIs). Nefazodone functions by modulating serotonin levels in the brain, which helps improve mood and alleviate depressive symptoms. The chemical formula for nefazodone is C17H18ClN3O2S, and it features a complex structure that includes a phenylpiperazine moiety and a thienyl group. It is typically administered in oral form and is known for its relatively favorable side effect profile compared to other antidepressants, although it can still cause drowsiness, dizziness, and gastrointestinal disturbances. Importantly, nefazodone has been associated with rare but serious liver toxicity, necessitating monitoring of liver function during treatment. The drug is metabolized primarily in the liver, and its pharmacokinetics can be influenced by various factors, including other medications and individual patient characteristics. Overall, nefazodone represents a unique option in the pharmacological management of depression.

Formula: C₂₅H₃₂ClN₅O₂

InChI: InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3

InChI key: InChIKey=VRBKIVRKKCLPHA-UHFFFAOYSA-N

SMILES: C(COC1=CC=CC=C1)N2C(CC)=NN(CCCN3CCN(CC3)C4=CC(Cl)=CC=C4)C2=O

Synonyms:

• 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one
• Nefazodone
• 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-

3H-1,2,4-Triazol-3-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-

CAS: 83366-66-9

Formula: C₂₅H₃₂ClN₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 470.0069

Ref: IN-DA00IDAO

Nefazodone

CAS: 83366-66-9

Nefazodone

Purity: ≥98%

Molecular weight: 470.01g/mol

Ref: 54-BUP20883

Nefazodone

CAS: 83366-66-9

Formula: C₂₅H₃₂ClN₅O₂

Purity: ≥ 98%

Color and Shape: Yellow oily liquid

Molecular weight: 470.01

Ref: 7W-GP3168

Nefazodone

CAS: 83366-66-9

Nefazodone (Nefadar) is an oral antidepressant that is an antagonist of postsynaptic 5-HT 2A receptors and 5-HT 2C receptors, and SNDRI.

Formula: C₂₅H₃₂ClN₅O₂

Purity: 99.85%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 470.01

Ref: TM-T21451

Nefazodone Hydrochloride

CAS: 82752-99-6, 83366-66-9

Formula: C₂₅H₃₂ClN₅O₂·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 506.47

Ref: 3B-N1030