CAS 834153-87-6

Elagolix

Description:

Elagolix is a synthetic small molecule classified as a non-peptide gonadotropin-releasing hormone (GnRH) antagonist. It is primarily used in the treatment of conditions such as endometriosis and uterine fibroids by inhibiting the secretion of gonadotropins, which in turn reduces estrogen production. The chemical formula of Elagolix reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. It is characterized by its ability to selectively bind to GnRH receptors, thereby blocking the downstream signaling pathways that lead to the production of sex hormones. Elagolix is administered orally and has a relatively short half-life, necessitating daily dosing for therapeutic efficacy. Its development has provided a significant advancement in the management of hormone-dependent disorders, offering an alternative to surgical interventions and other hormonal therapies. As with any medication, potential side effects may include hot flashes, headaches, and changes in bone density, which should be monitored during treatment.

Formula: C₃₂H₃₀F₅N₃O₅

InChI: InChI=1S/C32H30F5N3O5/c1-19-28(21-11-6-14-26(45-2)29(21)34)30(43)40(18-25(20-9-4-3-5-10-20)38-16-8-15-27(41)42)31(44)39(19)17-22-23(32(35,36)37)12-7-13-24(22)33/h3-7,9-14,25,38H,8,15-18H2,1-2H3,(H,41,42)/t25-/m0/s1

InChI key: InChIKey=HEAUOKZIVMZVQL-VWLOTQADSA-N

SMILES: CC1=C(C(=O)N(C[C@H](NCCCC(O)=O)C2=CC=CC=C2)C(=O)N1CC3=C(C(F)(F)F)C=CC=C3F)C4=C(F)C(OC)=CC=C4

Synonyms:

• (R)-4-((2-(5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoic acid
• 4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]butanoic acid
• Butanoic acid, 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]-
• Nbi 56418
• Elagolix

(R)-Elagolix

CAS: 834153-87-6

(R)-Elagolix (NBI-56418) is an orally active, highly selective, short-term potent antagonist of the non-peptide gonadotropin-releasing hormone receptor.

Formula: C₃₂H₃₀F₅N₃O₅

Purity: 99.08%

Color and Shape: Solid

Molecular weight: 631.59

Ref: TM-T11174

4-{[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-4-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl]-1-phenylethyl]amino}butanoic acid

CAS: 834153-87-6

Formula: C₃₂H₃₀F₅N₃O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 631.5897

Ref: IN-DA00G3RS

(R)-Elagolix

CAS: 834153-87-6

(R)-Elagolix

Purity: ≥95%

Molecular weight: 631.59g/mol

Ref: 54-BUP09633

Elagolix-d6

CAS: 834153-87-6

Formula: C₃₂H₂₄D₆F₅N₃O₅

Molecular weight: 637.64

Ref: 4Z-E-150003

Elagolix

Controlled Product

CAS: 834153-87-6

Applications Elagolix has a potential role for treating uterine bleeding associated to uterine myomas. Elagolix is also used in the methods for treatment of estrogen-dependent disorders including gonadotropin-releasing hormone (GnRH) antagonists in combination with add-back therapy.
References Barra, F., et al.: Expert. Opin. Pharmaco. (2020); Gotteland, J.-P., et al.: PCT Int. Appl. 268pp. (2020)

Formula: C₃₂H₃₀F₅N₃O₅

Color and Shape: Neat

Molecular weight: 631.59

Ref: TR-E501180

Elagolix

CAS: 834153-87-6

Non-peptide GnRHR hormone receptor antagonist

Formula: C₃₂H₃₀F₅N₃O₅

Purity: Min. 95%

Molecular weight: 631.59 g/mol

Ref: 3D-FE63183