CAS 83435-66-9: Delapril

Description: Delapril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. As a prodrug, it is converted in the body to its active form, which helps to relax blood vessels and reduce blood pressure. The chemical structure of Delapril includes a carboxylic acid group, which is essential for its pharmacological activity. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and improving blood flow. Delapril is typically administered orally and is known for its relatively favorable side effect profile compared to other antihypertensive agents. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. As with other ACE inhibitors, it is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy and should be used cautiously in individuals with renal impairment. Overall, Delapril represents an important therapeutic option in managing cardiovascular conditions.

Formula: C₂₆H₃₂N₂O₅

InChI: InChI=1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1

InChI key: InChIKey=WOUOLAUOZXOLJQ-MBSDFSHPSA-N

SMILES: O=C(O)CN(C(=O)C(NC(C(=O)OCC)CCC=1C=CC=CC1)C)C2CC=3C=CC=CC3C2

Synonyms:

• Alindapril
• Delapril [INN]
• Delaprilum
• Delaprilum [Latin]
• Glycine, N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)-
• Glycine, N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-, (S)-
• Glycine, N-(2,3-dihydro-1H-inden-2-yl)-N-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-<span class="text-smallcaps">L</span>-alanyl]-, (S)-
• Glycine, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-<span class="text-smallcaps">L</span>-alanyl-N-(2,3-dihydro-1H-inden-2-yl)-
• Indalapril
• N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-<span class="text-smallcaps">L</span>-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine
• N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine
• Unii-W77Ual9Thi
• Delapril

Delapril Hydrochloride

CAS: 83435-66-983435-67-0

• Formula: C₂₆H₃₂N₂O₅·HCl
• Purity: >97.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 489.01

Delapril

CAS: 83435-66-9

• Formula: C₂₆H₃₂N₂O₅
• Molecular weight: 452.5427

Delapril

CAS: 83435-66-9

• Formula: C₂₆H₃₂N₂O₅
• Molecular weight: 452.54

Delapril

CAS: 83435-66-9

• Formula: C₂₆H₃₂N₂O₅
• Molecular weight: 452.55

Delapril

CAS: 83435-66-9

Delapril is an ACE inhibitor. It blocks the conversion of angiotensin I to angiotensin II.

• Formula: C₂₆H₃₂N₂O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 452.54