CAS 83462-55-9

Deoxypyridinoline

Description:

Deoxypyridinoline (DPD) is a pyridinoline derivative and a cross-linking marker of collagen, primarily found in bone and cartilage. It is a product of collagen degradation and is often used as a biochemical marker for bone resorption in clinical settings. DPD is characterized by its ability to form stable cross-links between collagen fibers, which contributes to the structural integrity and mechanical strength of connective tissues. The substance is typically measured in urine, providing insights into bone metabolism and turnover. Elevated levels of DPD can indicate increased bone resorption, which may be associated with conditions such as osteoporosis or other metabolic bone diseases. In terms of its chemical structure, DPD contains a pyridine ring and is classified as a heterocyclic compound. Its analysis often involves techniques such as high-performance liquid chromatography (HPLC) or mass spectrometry. Overall, deoxypyridinoline serves as a valuable biomarker in the assessment of bone health and the evaluation of therapeutic interventions in bone-related disorders.

Formula: C₁₈H₂₈N₄O₇

InChI: InChI=1S/C18H28N4O7/c19-12(16(24)25)3-1-2-6-22-8-10(4-5-13(20)17(26)27)11(15(23)9-22)7-14(21)18(28)29/h8-9,12-14H,1-7,19-21H2,(H3-,23,24,25,26,27,28,29)/t12-,13-,14-/m0/s1

InChI key: InChIKey=ZAHDXEIQWWLQQL-IHRRRGAJSA-N

SMILES: C(C[C@@H](C(O)=O)N)C=1C(C[C@@H](C(O)=O)N)=C(O)C=[N+](CCCC[C@@H](C([O-])=O)N)C1

Synonyms:

• 4-[(2S)-2-amino-2-carboxyethyl]-1-[(5S)-5-amino-5-carboxypentyl]-5-[(3S)-3-amino-3-carboxypropyl]pyridinium-3-olate
• 90032-33-0
• Deoxypyridinoline
• Lysylpyridinoline
• Pyridinium, 4-(2-amino-2-carboxyethyl)-1-(5-amino-5-carboxypentyl)-3-(3-amino-3-carboxypropyl)-5-hydroxy-, inner salt, stereoisomer
• Pyridinium, 4-[(2S)-2-amino-2-carboxyethyl]-1-[(5S)-5-amino-5-carboxypentyl]-3-[(3S)-3-amino-3-carboxypropyl]-5-hydroxy-, inner salt

Deoxy Pyridinoline

CAS: 83462-55-9

Formula: C₁₈H₂₈N₄O₇

Color and Shape: Off-White To Pale Yellow Solid

Molecular weight: 412.44

Ref: 4Z-P-10801

Deoxy Pyridinoline-d5

CAS: 83462-55-9

Formula: C₁₈H₂₃N₄O₇D₅

Molecular weight: 417.48

Ref: 4Z-P-10804

Deoxypyridinoline

CAS: 83462-55-9

Deoxypyridinoline is a marker of oxidative stress in the human body. It is released when reactive oxygen species (ROS) break down proteins, lipids, and DNA. Deoxypyridinoline is found at high levels in patients with inflammatory bowel disease and also shows high values in geriatric patients. This marker can be used as an indicator for disease activity in autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus. The deoxypyridinoline level increases after the onset of these diseases, but decreases during remission periods.

Formula: C₁₈H₂₈N₄O₇

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 412.44 g/mol

Ref: 3D-FD179473