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CAS 835-31-4

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Naphazoline

Description:
Naphazoline is a sympathomimetic agent primarily used as a topical decongestant in nasal sprays and eye drops. It belongs to the imidazoline class of compounds and acts primarily as an alpha-adrenergic agonist, leading to vasoconstriction and reduced swelling in mucous membranes. Naphazoline is characterized by its rapid onset of action and relatively short duration of effect, making it effective for temporary relief of nasal congestion and redness in the eyes. The compound is typically administered in low concentrations due to its potency and potential side effects, which can include rebound congestion, irritation, and increased blood pressure with prolonged use. Naphazoline is generally well-tolerated when used as directed, but caution is advised in patients with cardiovascular conditions or those taking monoamine oxidase inhibitors. Its chemical structure features a naphthalene ring, contributing to its lipophilicity, which aids in its absorption and efficacy in target tissues.
Formula:C14H14N2
InChI:InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
InChI key:InChIKey=CNIIGCLFLJGOGP-UHFFFAOYSA-N
SMILES:C(C=1C2=C(C=CC1)C=CC=C2)C=3NCCN3
Synonyms:
  • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
  • 2-(1-Naphthalenylmethyl)-2-imidazoline
  • 2-(1-Naphthylmethyl)-2-Imidazoline
  • 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
  • 2-Imidazoline, 2-(1-naphthylmethyl)-
  • 2-[(Naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole
  • 4,5-Dihydro-2-(1-naphthalenylmethyl)-1H-imidazole
  • Antan
  • Antigaimorit
  • Colirio Alfa
  • See more synonyms
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