CAS 83526-33-4

5-hydroxy-N-(piperidin-2-ylmethyl)-2-(2,2,2-trifluoroethoxy)benzamide

Description:

5-Hydroxy-N-(piperidin-2-ylmethyl)-2-(2,2,2-trifluoroethoxy)benzamide, with the CAS number 83526-33-4, is a chemical compound characterized by its complex structure that includes a benzamide core substituted with a hydroxy group and a trifluoroethoxy moiety. The presence of the piperidine ring contributes to its potential biological activity, as piperidine derivatives are often found in pharmaceuticals. The trifluoroethoxy group enhances lipophilicity, which can influence the compound's solubility and permeability in biological systems. This compound may exhibit specific interactions with biological targets, making it of interest in medicinal chemistry. Its unique functional groups suggest potential applications in drug development, particularly in areas targeting central nervous system disorders or other therapeutic areas. As with many synthetic compounds, understanding its pharmacokinetics, toxicity, and mechanism of action would be crucial for evaluating its suitability for therapeutic use.

Formula: C₁₅H₁₉F₃N₂O₃

InChI: InChI=1/C15H19F3N2O3/c16-15(17,18)9-23-13-5-4-11(21)7-12(13)14(22)20-8-10-3-1-2-6-19-10/h4-5,7,10,19,21H,1-3,6,8-9H2,(H,20,22)

SMILES: C1CCNC(C1)CN=C(c1cc(ccc1OCC(F)(F)F)O)O

Synonyms:

• benzamide, 5-hydroxy-N-(2-piperidinylmethyl)-2-(2,2,2-trifluoroethoxy)-

Flecainide Meta-O-dealkylated

Controlled Product

CAS: 83526-33-4

Applications Flecainide Meta-O-dealkylated is a major metabolite of Flecainide (F390000), an antiarrhythmic (class IC).
References Benijts, T., et. al.: J. Anal. Toxicol., 27, 47 (2003); Hodess, A.B., et al.: J. Cardiovasc. Pharmacol., 1, 427 (1979); Somani, P., et al.: Clin. Pharmacol. Ther., 27, 464 (1980); Alessi-Severini, S., et al.: Anal. Profiles Drug Subs. Excip., 21, 169 (1992)

Formula: C₁₅H₁₉F₃N₂O₃

Color and Shape: Neat

Molecular weight: 332.32

Ref: TR-F390005