CAS 835876-32-9

Platensimycin

Description:

Platensimycin is a natural product and a member of the platensimycin class of antibiotics, primarily known for its antibacterial properties. It is derived from the bacterium *Streptomyces platensis*. This compound exhibits a unique mechanism of action by inhibiting fatty acid biosynthesis, specifically targeting the enzyme FabF, which is crucial for the synthesis of fatty acids in bacteria. Platensimycin has shown effectiveness against a range of Gram-positive bacteria, including strains resistant to conventional antibiotics. Its structure features a complex bicyclic core with multiple functional groups, contributing to its biological activity. Additionally, platensimycin has garnered interest in pharmaceutical research due to its potential as a lead compound for developing new antibiotics in the face of rising antibiotic resistance. However, its clinical use has been limited, and further studies are necessary to explore its full therapeutic potential and safety profile. Overall, platensimycin represents a promising avenue in the search for novel antimicrobial agents.

Formula: C₂₄H₂₇NO₇

InChI: InChI=1S/C24H27NO7/c1-22(7-6-17(28)25-18-14(26)4-3-13(19(18)29)21(30)31)16(27)5-8-24-10-12-9-15(20(22)24)32-23(12,2)11-24/h3-5,8,12,15,20,26,29H,6-7,9-11H2,1-2H3,(H,25,28)(H,30,31)/t12-,15+,20+,22-,23+,24+/m1/s1

InChI key: InChIKey=CSOMAHTTWTVBFL-OFBLZTNGSA-N

SMILES: C(CC(NC1=C(O)C(C(O)=O)=CC=C1O)=O)[C@@]2(C)[C@]3([C@]4(C[C@@]5([C@](C)(C4)O[C@]3(C5)[H])[H])C=CC2=O)[H]

Synonyms:

• (-)-Platensimycin
• 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-Hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxybenzoic acid
• Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
• Platensimycin
• laminomycin
• Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem

Platensimycin

CAS: 835876-32-9

Platensimycin (PTM): S. platensis antibiotic, inhibits Gram-positive bacteria, blocks lipid making (IC50=0.1μM), may combat antibiotic resistance.

Formula: C₂₄H₂₇NO₇

Color and Shape: Solid

Molecular weight: 441.47

Ref: TM-T35634