CAS 83602-05-5

Spiraprilat

Description:

Spiraprilat is a chemical compound that serves as an active metabolite of the angiotensin-converting enzyme (ACE) inhibitor spirapril. It is primarily characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, thereby playing a significant role in the regulation of blood pressure. Spiraprilat exhibits a high affinity for the ACE enzyme, contributing to its effectiveness in managing hypertension. The compound is typically administered in its prodrug form, spirapril, which is converted to spiraprilat in the body. Spiraprilat is known for its long duration of action and is often evaluated for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion. Additionally, it may have implications in the treatment of heart failure and other cardiovascular conditions. As with many ACE inhibitors, potential side effects can include cough, elevated potassium levels, and hypotension. Overall, spiraprilat represents a significant advancement in the pharmacological management of cardiovascular diseases.

Formula: C₂₀H₂₆N₂O₅S₂

InChI: InChI=1S/C20H26N2O5S2/c1-13(21-15(18(24)25)8-7-14-5-3-2-4-6-14)17(23)22-12-20(28-9-10-29-20)11-16(22)19(26)27/h2-6,13,15-16,21H,7-12H2,1H3,(H,24,25)(H,26,27)/t13-,15-,16-/m0/s1

InChI key: InChIKey=FMMDBLMCSDRUPA-BPUTZDHNSA-N

SMILES: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2CC3(C[C@H]2C(O)=O)SCCS3

Synonyms:

• Spiraprilat
• Spiraprilic acid
• 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-, [8S-[7[R*(R*)],8R*]]-
• Sch 33861
• 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-, (8S)-

Spiraprilat

CAS: 83602-05-5

Spiraprilat is an ACE inhibitor. It also is an active metabolite of spirapril.

Formula: C₂₀H₂₆N₂O₅S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 438.56

Ref: TM-T24820