CAS 83602-39-5
:Cyclosporin H
Description:
Cyclosporin H, with the CAS number 83602-39-5, is a cyclic polypeptide that belongs to the class of immunosuppressive agents. It is derived from the fungus Tolypocladium inflatum and is structurally related to cyclosporine A, differing primarily in its amino acid composition. Cyclosporin H exhibits potent immunosuppressive properties, making it valuable in preventing organ transplant rejection and treating autoimmune diseases. Its mechanism of action involves the inhibition of T-cell activation and proliferation by binding to cyclophilin, which subsequently inhibits calcineurin, a critical enzyme in T-cell signaling pathways. The substance is lipophilic, which affects its solubility and bioavailability, and it is typically administered orally or intravenously. Due to its immunosuppressive effects, careful monitoring of patients is essential to manage potential side effects, including increased susceptibility to infections and nephrotoxicity. Overall, Cyclosporin H represents an important therapeutic agent in clinical settings, particularly in transplant medicine.
Formula:C63H113N11O12
InChI:InChI=1/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-42(16)54(77)65-43(17)57(80)70(21)47(32-37(7)8)59(82)71(22)48(33-38(9)10)61(84)73(24)51(40(13)14)63(86)74(52)25/h26,28,35-48,50-53,76H,27,29-34H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)/b28-26+/t41-,42+,43-,44+,45+,46+,47-,48+,50-,51+,52?,53-/m1/s1
Synonyms:- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- (3S,6S,9R,12R,15S,18S,21R,24S,30S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,22,25,28-decamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
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Found 11 products.
Cyclosporin H
CAS:Formula:C62H111N11O12Color and Shape:White To Off-White SolidMolecular weight:1202.64Cyclosporin H
CAS:<p>Cyclosporin H inhibits FPR1, reduces lung inflammation and MAPK/AKT activity, boosts viral transduction, and lacks Cyclosporin A immunosuppression.</p>Formula:C62H111N11O12Purity:99.87% - 99.94%Color and Shape:White Crystalline PowerMolecular weight:1202.61Iso Cyclosporin H Trifluoroacetic Acid Salt
CAS:<p>Stability Hygroscopic<br>Applications Iso Cyclosporin H is an impurity of Cyclosporin H (C988920).<br>References Borel, J., et al.: Pharmacol. Rev., 41, 259 (1990); Brooks, C., et al.: Clin. Chem., 39, 457 (1993); Lee, Y., et al.: J. Pharm. Biomed. Anal., 22, 183 (2000);<br></p>Formula:C62H111N11O12·x(C2HF3O2)Purity:>75% by HPLCColor and Shape:NeatMolecular weight:1202.61 + x(114.02)Cyclosporin H
CAS:<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C62H111N11O12Color and Shape:NeatMolecular weight:1202.61Cyclosporin H
CAS:<p>Formyl peptide receptor-1 (FPR-1) antagonist</p>Formula:C62H111N11O12Purity:Min. 95%Color and Shape:PowderMolecular weight:1,202.61 g/molCyclosporin H
CAS:Lactams, nesoiFormula:C62H111N11O12Color and Shape:White Off-White SolidMolecular weight:1201.84137
