CAS 83602-41-9

(1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,26,31-nonamethyl-14,32-bis(1-methylethyl)-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacont

Description:

The chemical substance with the name "(1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,26,31-nonamethyl-14,32-bis(1-methylethyl)-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacont" and CAS number "83602-41-9" is a complex organic compound characterized by its intricate structure, which includes multiple chiral centers and a significant number of functional groups. This substance likely exhibits a high molecular weight due to its extensive carbon backbone and numerous substituents, contributing to its potential biological activity. The presence of multiple oxo groups suggests it may have applications in medicinal chemistry or materials science. Additionally, the stereochemistry indicated by the R and S designations implies that the compound may exhibit specific interactions with biological targets, making it of interest in pharmacology. Its solubility, stability, and reactivity would depend on the specific functional groups and overall molecular architecture, which could influence its behavior in various chemical environments.

Formula: C₆₄H₁₁₃N₁₁O₁₃

InChI: InChI=1/C64H113N11O13/c1-26-28-29-41(15)53(88-44(18)76)52-57(81)67-45(27-2)59(83)70(20)34-49(77)71(21)47(31-36(5)6)56(80)69-50(39(11)12)61(85)72(22)48(32-37(7)8)55(79)65-42(16)54(78)66-43(17)58(82)75(25)64(19,33-38(9)10)63(87)68-46(30-35(3)4)60(84)73(23)51(40(13)14)62(86)74(52)24/h26,28,35-43,45-48,50-53H,27,29-34H2,1-25H3,(H,65,79)(H,66,78)(H,67,81)(H,68,87)(H,69,80)/b28-26+/t41-,42+,43-,45+,46+,47+,48+,50+,51+,52+,53-,64+/m1/s1

Synonyms:

• o-Acetyl C(9) cyclosporin a
• Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoic acid]-
• (3R,4R)-3-Acetoxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• Cyclosporin A Acetate
• Aids097134
• (3R,4R)-3-Acetoxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• SDZ 33-243
• Sdz 033-243
• Cyclosporin A O-Acetyl Impurity
• (3R,4R)-N-Methyl-3-acetoxy-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• O-Acetylcyclosporin A
• Cyclosporine A acetate
• 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-Methyl-2-(MethylaMino)-6-octenoic acid] Cyclosporin A
• Acetylcyclosporin A
• B-3-243
• Aids-097134

Cyclosporin A Acetate

CAS: 83602-41-9

Formula: C₂₆H₄₆N₃O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 480.6605

Ref: IN-DA0057EE

Cyclosporin A-13C2,d4 Acetate

Controlled Product

CAS: 83602-41-9

Applications Labelled Cyclosporin A (C988901) derivative. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005)

Formula: C₆₂C₂H₁₀₉D₄N₁₁O₁₃

Color and Shape: Neat

Molecular weight: 1250.65

Ref: TR-C988893

Cyclosporin A-d4 Acetate (Major)

Controlled Product

CAS: 83602-41-9

Applications A non-immunosuppressive analog of Cyclosporin A.
References Twentyman, P. R., et al.: Brit. J. Cancer, 57, 254 (1988), Twentyman, P. R., et al.: Brit. J. Cancer, 65, 335 (1992), Schneider, H., et al.: Biochem., 33, 8218 (1994).

Formula: C₆₄H₁₀₉D₄N₁₁O₁₃

Color and Shape: Neat

Molecular weight: 1248.67

Ref: TR-C988892

Cyclosporin A acetate

CAS: 83602-41-9

Cyclosporin A is a cyclic non-hydrolyzable glycol ester that inhibits the production of cytokines and inflammatory mediators by binding to specific intracellular receptors. Cyclosporin A acetate is an inactive prodrug that is converted to active cyclosporine in the liver. Cyclosporin A acetate has been shown to be effective in treating autoimmune diseases such as rheumatoid arthritis and psoriasis, as well as atopic dermatitis. Cyclosporin A acetate is used orally and usually taken with food or milk to reduce gastrointestinal irritation. The oral dosage form of this drug contains saccharose as a diluent and surfactant, which reduces the risk of gastrointestinal irritation.

Formula: C₆₄H₁₁₃N₁₁O₁₃

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 1,244.65 g/mol

Ref: 3D-FC20751

Cyclosporin A Acetate

CAS: 83602-41-9

Formula: C₆₄H₁₁₃N₁₁O₁₃

Molecular weight: 1244.7

Ref: ST-EA-CP-C162052