CAS 83647-33-0

N-Desmethyldroloxifene

Description:

N-Desmethyldroloxifene is a chemical compound that belongs to the class of selective estrogen receptor modulators (SERMs). It is a derivative of the drug droloxifene, which is used primarily in the treatment of breast cancer. The compound exhibits both estrogenic and anti-estrogenic properties, making it useful in various therapeutic applications. N-Desmethyldroloxifene is characterized by its ability to bind to estrogen receptors, influencing gene expression and cellular activity in tissues responsive to estrogen. Its pharmacological profile suggests potential benefits in managing conditions related to estrogen imbalance, such as osteoporosis and certain types of breast cancer. The compound's chemical structure includes a phenolic group, contributing to its biological activity. Additionally, it is important to consider its solubility, stability, and metabolic pathways when evaluating its therapeutic potential and safety profile. As with many SERMs, ongoing research is essential to fully understand its efficacy and side effects in clinical settings.

Formula: C₂₅H₂₇NO₂

InChI: InChI=1S/C25H27NO2/c1-3-24(19-8-5-4-6-9-19)25(21-10-7-11-22(27)18-21)20-12-14-23(15-13-20)28-17-16-26-2/h4-15,18,26-27H,3,16-17H2,1-2H3/b25-24+

InChI key: InChIKey=QPHNKIXIKDPNDI-OCOZRVBESA-N

SMILES: C(=C(\CC)/C1=CC=CC=C1)(\C2=CC(O)=CC=C2)/C3=CC=C(OCCNC)C=C3

Synonyms:

• 3-[(1E)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
• K 106
• N-Desmethyl-3-hydroxytamoxifen
• N-Desmethyldroloxifene
• Phenol, 3-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-, (E)-
• Phenol, 3-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
• Phenol, 3-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-

N-Desmethyl Droloxifene (contains up to 5% Z isomer)

Controlled Product

CAS: 83647-33-0

Formula: C₂₅H₂₇NO₂

Color and Shape: Neat

Molecular weight: 373.49

Ref: TR-D292025