CAS 83647-97-6

Spirapril

Description:

Spirapril is a pharmaceutical compound classified as an angiotensin-converting enzyme (ACE) inhibitor, primarily used in the treatment of hypertension and heart failure. Its chemical structure features a unique combination of a thiazole ring and a proline derivative, which contribute to its mechanism of action by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This inhibition leads to vasodilation, reduced blood pressure, and decreased workload on the heart. Spirapril is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing in many cases. Common side effects may include dizziness, cough, and elevated potassium levels, similar to other ACE inhibitors. As with any medication, it is essential to monitor patients for potential adverse effects and interactions with other drugs. Spirapril's efficacy and safety profile make it a valuable option in managing cardiovascular conditions, although its use may be limited by individual patient factors and contraindications.

Formula: C₂₂H₃₀N₂O₅S₂

InChI: InChI=1S/C22H30N2O5S2/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27)/t15-,17-,18-/m0/s1

InChI key: InChIKey=HRWCVUIFMSZDJS-SZMVWBNQSA-N

SMILES: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2CC3(C[C@H]2C(O)=O)SCCS3

Synonyms:

• (8S)-7-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid (non-preferred name)
• 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-, [8S-[7[R*(R*)],8R*]]-
• Spirapril
• 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-, (8S)-
• Sch 33844
• (8S)-7-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
• 7-(2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid (non-preferred name)

spirapril

CAS: 83647-97-6

Formula: C₂₂H₃₀N₂O₅S₂

Molecular weight: 466.6140

Ref: IN-DA00G28K

Spirapril

CAS: 83647-97-6

Formula: C₂₂H₃₀N₂O₅S₂

Molecular weight: 466.61

Ref: 7W-GP8990

Spirapril

CAS: 83647-97-6

Spiropril is an ACE inhibitor antihypertensive drug, which belongs to the bicarboxyl group of ACE inhibitors and is used in the treatment of hypertension.

Formula: C₂₂H₃₀N₂O₅S₂

Color and Shape: Solid

Molecular weight: 466.61

Ref: TM-T34696