CAS 83651-90-5

calcitonin gene-rel. peptide

Description:

Calcitonin gene-related peptide (CGRP) is a neuropeptide that plays a significant role in various physiological processes, particularly in the nervous system and cardiovascular regulation. It is derived from the calcitonin gene and is known for its potent vasodilatory effects, which contribute to the regulation of blood flow and blood pressure. CGRP is composed of 37 amino acids and is primarily found in the central and peripheral nervous systems. It is involved in pain transmission and has been implicated in migraine pathophysiology, making it a target for migraine treatments. Additionally, CGRP has roles in inflammation and neurogenic processes. The peptide exists in two isoforms, alpha and beta, which differ slightly in their amino acid sequences but share similar biological functions. Due to its diverse roles, CGRP is of significant interest in pharmacology, particularly in the development of therapies for migraine and other pain-related conditions. Its CAS number, 83651-90-5, is used for identification in chemical databases and regulatory contexts.

Formula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Synonyms:

• .alpha.-CGRP (rat)
• H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bond)

α-CGRP (mouse, rat)

CAS: 83651-90-5

Induces elevation of cAMP and cGMP in rat aorta.

Formula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Purity: 96.8%

Color and Shape: White

Molecular weight: 3806.3

Ref: 01-4025897

α-CGRP, rat

CAS: 83651-90-5

Endogenous neuropeptide, potent vasodilator

Formula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 3806.25

Ref: TM-TP2233

CGRP (Rat)

CAS: 83651-90-5

CGRP (Rat) product with the disulfide Bonds: Cys2-Cys7 and available as a 0.1 mg vial. CGRP is the calcitonin gene-related peptide (CGRP), a neuropeptide that plays an important role in the regulation of vascular tone and blood flow, as well as pain perception, inflammation, and neurogenic inflammation. It is a potent vasodilator and has been implicated in a wide range of physiological and pathophysiological processes.
This product has the potential for use in the study of the physiological and pathological roles of CGRP and to investigate the effects of CGRP on blood vessels, neurons, and other tissues. It has also been used to develop models of migraine headaches and other conditions associated with CGRP dysfunction.

Formula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Purity: Min. 95%

Molecular weight: 3,806.2 g/mol

Ref: 3D-PCG-4163-S

α-CGRP (mouse, rat)

CAS: 83651-90-5

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist which is secreted in both peripheral and central neurons. It is a potent vasodilator and can function in the transmission of nociception as well as acting as an appetite suppressant and contributing to gastric acid secretion.  It also has a function in temperature homeostasis, increases heart rate, and can play a role in the release of the pituitary hormone.

Formula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 3,806.25 g/mol

Ref: 3D-CRB1000889

CGRP (Rat)

CAS: 83651-90-5

CGRP (Rat) product with the disulfide Bonds: Cys2-Cys7 and available as a 0.5mg vial. CGRP is the calcitonin gene-related peptide (CGRP), a neuropeptide that plays an important role in the regulation of vascular tone and blood flow, as well as pain perception, inflammation, and neurogenic inflammation. It is a potent vasodilator and has been implicated in a wide range of physiological and pathophysiological processes.
This product has the potential for use in the study of the physiological and pathological roles of CGRP and to investigate the effects of CGRP on blood vessels, neurons, and other tissues. It has also been used to develop models of migraine headaches and other conditions associated with CGRP dysfunction.

Purity: Min. 95%

Ref: 3D-PCG-4163-V