CAS 837-52-5

7-chloro-4-piperazin-1-yl-quinoline

Description:

7-Chloro-4-piperazin-1-yl-quinoline, with the CAS number 837-52-5, is a chemical compound that belongs to the class of quinolines, which are bicyclic aromatic compounds. This substance features a quinoline core substituted with a chlorine atom at the 7-position and a piperazine ring at the 4-position. The presence of the piperazine moiety contributes to its potential biological activity, as piperazines are often associated with pharmacological properties. The compound is typically characterized by its molecular structure, which includes a nitrogen-containing heterocyclic ring, making it polar and capable of forming hydrogen bonds. It may exhibit solubility in polar solvents, and its reactivity can be influenced by the electron-withdrawing chlorine substituent. 7-Chloro-4-piperazin-1-yl-quinoline has been studied for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting various biological pathways. However, specific safety and handling information should be consulted from material safety data sheets (MSDS) or relevant literature before use.

Formula: C₁₃H₁₄ClN₃

InChI: InChI=1/C13H14ClN3/c14-11-3-1-10-2-4-13(16-12(10)9-11)17-7-5-15-6-8-17/h1-4,9,15H,5-8H2

SMILES: c1cc(cc2c1ccc(n2)N1CCNCC1)Cl

Synonyms:

• 7-Chloro-2-(Piperazin-1-Yl)Quinoline
• 7-Chloro-4-piperazinoquinoline

7-Chloro-4-(piperazin-1-yl)quinoline

CAS: 837-52-5

Formula: C₁₃H₁₄ClN₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 247.7234

Ref: IN-DA003NEK

Piperaquine Impurity 6 (7-Chloro-4-Piperazinylquinoline)

CAS: 837-52-5

Formula: C₁₃H₁₄ClN₃

Color and Shape: White To Off-White Solid

Molecular weight: 247.73

Ref: 4Z-P-228

7-Chloro-4-(piperazin-1-yl)quinoline

CAS: 837-52-5

7-Chloro-4-(piperazin-1-yl)quinoline

Purity: 97%

Color and Shape: Off-White Solid

Molecular weight: 247.72g/mol

Ref: 54-OR8697

7-Chloro-4-piperazinylquinoline

CAS: 837-52-5

Purity: 95.0%

Color and Shape: Liquid, No data available.

Molecular weight: 247.72999572753906

Ref: 10-F076737

7-Chloro-4-(piperazin-1-yl)quinoline

CAS: 837-52-5

7-Cl-4-(piperazin-1-yl)quinolone: sirtuin inhibitor, serotonin uptake blocker, antimalarial (D10 IC50 1.18µM, K1 IC50 0.97µM).

Formula: C₁₃H₁₄ClN₃

Purity: 99.52%

Color and Shape: Light Yellow Solid

Molecular weight: 247.72

Ref: TM-Fr13587

Piperaquine Impurity A

CAS: 837-52-5

Formula: C₁₃H₁₄ClN₃

Molecular weight: 247.73

Ref: ST-EA-CP-P19001

7-Chloro-4-(piperazin-1-yl)quinoline

Controlled Product

CAS: 837-52-5

Applications 7-Chloro-4-(piperazin-1-yl)quinoline is a metabolite of Piperaquine phosphate (P480050), a low toxicity and quick acting antimalarial drug that is used to treat malaria.
References Aditya, S.: J. Drug Dis. Ther., 1, No pp. given (2013); Ahmed, T., et al.: J. Clin. Pharm., 48, 166 (2008); Gargano, N.,et al.: Trop. Med. Int. Health, 16, 1466 (2011)

Formula: C₁₃H₁₄ClN₃

Color and Shape: Neat

Molecular weight: 247.72

Ref: TR-C380330

7-Chloro-4-(piperazin-1-yl)quinoline-d8

Controlled Product

CAS: 837-52-5

Formula: C₁₃D₈H₆ClN₃

Color and Shape: Neat

Molecular weight: 255.773

Ref: TR-C380332

7-Chloro-4-piperazinylquinoline

CAS: 837-52-5

7-Chloro-4-piperazinylquinoline is a quinoline derivative that belongs to the group of organic solvents. It has anticancer activity and is used as a medicine. 7-Chloro-4-piperazinylquinoline is used as an intermediate in the preparation of sorafenib, which is a potent inhibitor of the protein tyrosine kinase. Sorafenib inhibits cancer cell proliferation and tumor growth by blocking the activity of tyrosine kinases, which are necessary for cellular proliferation and survival. It also inhibits phospholipase A2, which leads to cell death by apoptosis.

Formula: C₁₃H₁₄ClN₃

Purity: Min. 95%

Molecular weight: 247.72 g/mol

Ref: 3D-FC42406