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CAS 83709-73-3

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12-epi-LTB4

Description:
12-epi-LTB4, with the CAS number 83709-73-3, is a biologically active lipid mediator derived from arachidonic acid. It is a member of the leukotriene family, specifically a stereoisomer of leukotriene B4 (LTB4), which plays a crucial role in inflammatory responses and immune system regulation. This compound is characterized by its ability to act as a potent chemotactic agent, attracting immune cells to sites of inflammation. It exhibits various biological activities, including promoting the adhesion and migration of leukocytes, enhancing vascular permeability, and influencing the production of other inflammatory mediators. The structural distinction of 12-epi-LTB4 from its parent compound lies in the configuration around the carbon atom at the 12 position, which can affect its receptor binding and biological activity. As a result, 12-epi-LTB4 may have unique pharmacological properties that differentiate it from LTB4, making it a subject of interest in research related to inflammation and immune responses.
Formula:C20H32O4
InChI:InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1
InChI key:InChIKey=VNYSSYRCGWBHLG-CBBLYLIKSA-N
SMILES:C(=C\C=C\C=C\[C@H](C/C=C\CCCCC)O)\[C@H](CCCC(O)=O)O
Synonyms:
  • (5S,6Z,8E,10E,12S,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
  • 12(S)-Leukotriene B<sub>4</sub>
  • 12-epi-LTB<sub>4</sub>
  • 12-epi-Leukotriene B<sub>4</sub>
  • 5(S),12(S)-Dihydroxyeicosatetraenoic acid
  • 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12S,14Z)-
  • 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, [S-[R*,R*-(E,Z,E,Z)]]-
  • 83709-73-3
  • 12-epi-LTB4
  • 12(S)-Leukotriene B4
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