CAS 83799-24-0

Fexofenadine

Description:

Fexofenadine is a second-generation antihistamine primarily used to alleviate allergy symptoms such as hay fever and hives. It is characterized by its selective antagonism of peripheral H1 histamine receptors, which helps reduce symptoms without causing significant sedation, a common side effect of first-generation antihistamines. The chemical formula of fexofenadine is C32H39NO4, and it has a molecular weight of approximately 501.67 g/mol. Fexofenadine is known for its rapid absorption and extensive metabolism, primarily in the liver, with a bioavailability that is not significantly affected by food intake. It is typically administered orally and is available in various formulations, including tablets and suspensions. The substance is generally well-tolerated, with common side effects including headache and dizziness. Importantly, fexofenadine does not cross the blood-brain barrier to a significant extent, which contributes to its lower sedative effects compared to older antihistamines. Overall, fexofenadine is a widely used and effective medication for managing allergic conditions.

Formula: C₃₂H₃₉NO₄

InChI: InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)

InChI key: InChIKey=RWTNPBWLLIMQHL-UHFFFAOYSA-N

SMILES: C(O)(C1CCN(CCCC(O)C2=CC=C(C(C(O)=O)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms:

• 2-(4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl]-phenyl)-2-methyl-propionic acid
• 2-(4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl]phenyl)-2-methylpropanoic acid
• 2-[4-(1-Hydroxy-4-{4-[Hydroxy(Diphenyl)Methyl]Piperidin-1-Yl}Butyl)Phenyl]-2-Methylpropanoic Acid
• 4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethylbenzeneacetic acid
• 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylphenylacetic acid
• Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-
• Carboxyterfenadine
• Fexet
• Mdl 16455
• Telfast 120
• Terfenadine acid metabolite
• Terfenadine carboxylate

Fexofenadine Hydrochloride

CAS: 138452-21-8, 153439-40-8, 83799-24-0

Formula: C₃₂H₃₉NO₄·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 538.13

Ref: 3B-F0698

2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid

CAS: 83799-24-0

Formula: C₃₂H₃₉NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 501.6564

Ref: IN-DA00IDBU

Fexofenadine

CAS: 83799-24-0

Formula: C₃₂H₃₉NO₄

Purity: ≥ 98.0%

Color and Shape: White to beige powder

Molecular weight: 501.66

Ref: 7W-GP3042

Fexofenadine

CAS: 83799-24-0

Fexofenadine

Purity: ≥98%

Molecular weight: 501.66g/mol

Ref: 54-BUP15700

Fexofenadine

CAS: 83799-24-0

Fexofenadine

Purity: 95%

Molecular weight: 501.66g/mol

Ref: 54-OR1024611

Fexofenadine

CAS: 83799-24-0

Fexofenadine, a non-sedating antihistamine, treats allergies like hay fever and urticaria.

Formula: C₃₂H₃₉NO₄

Purity: 99.35%

Color and Shape: White To Off-White Solid

Molecular weight: 501.66

Ref: TM-T21390

Fexofenadine

Controlled Product

CAS: 83799-24-0

Applications The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.
References Garteiz, D.A., et al.: Arzneim.-Forsch., 32, 1185 (1982), Rampe, D., et al.: Mol. Pharmacol., 44, 1240 (1993), Obradovic, T., et al.: Pharm. Res., 24, 318 (2007),

Formula: C₃₂H₃₉NO₄

Color and Shape: Off-White

Molecular weight: 501.66

Ref: TR-F322470

Fexofenadine

CAS: 83799-24-0

Fexofenadine is a selective histamine H1 receptor antagonist that has been shown to be effective in the treatment of allergic rhinitis. It is well tolerated and does not have any significant drug interactions. Fexofenadine is metabolized by cytochrome P450 (CYP) enzymes and undergoes extensive first-pass metabolism. This means that it should not interact with CYP inhibitors such as ketoconazole or cimetidine, but may increase the effects of CYP inducers such as phenobarbital or rifampin. Fexofenadine has been shown to inhibit the activity of human multidrug resistance protein 1 (MDR1) and P-glycoprotein (P-gp).

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 501.66 g/mol

Ref: 3D-FF23281