CAS 838-07-3

5-Methyl-2′-deoxycytidine

Description:

5-Methyl-2′-deoxycytidine, commonly referred to as 5-mdC, is a modified nucleoside that plays a crucial role in the epigenetic regulation of gene expression. It is a derivative of deoxycytidine, where a methyl group is added to the carbon-5 position of the pyrimidine ring. This modification is significant in DNA methylation processes, influencing cellular functions such as differentiation, development, and genomic stability. The presence of 5-methylcytosine, the methylated form of cytosine, is a hallmark of mammalian DNA and is involved in the silencing of gene expression and the maintenance of heterochromatin. 5-Methyl-2′-deoxycytidine is often studied in the context of cancer research, as abnormal methylation patterns can lead to tumorigenesis. In terms of physical properties, it is typically a white to off-white crystalline powder, soluble in water and organic solvents. Its chemical structure allows it to participate in various biochemical reactions, making it a vital component in molecular biology and genetics research.

Formula: C₁₀H₁₅N₃O₄

InChI: InChI=1S/C10H15N3O4/c1-5-3-13(10(16)12-9(5)11)8-2-6(15)7(4-14)17-8/h3,6-8,14-15H,2,4H2,1H3,(H2,11,12,16)/t6-,7+,8+/m0/s1

InChI key: InChIKey=LUCHPKXVUGJYGU-XLPZGREQSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(C)C(N)=N1

Synonyms:

• 2-Deoxy-5-Methylcytidine
• 4-amino-1-(2-deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidin-2(1H)-one
• 4-amino-1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-methylpyrimidin-2(1H)-one
• 5-Methyldeoxycytidine
• Cytidine, 2′-deoxy-5-methyl-
• 5-Methyl-2′-deoxycytidine

2'-Deoxy-5-methylcytidine

CAS: 838-07-3

Formula: C₁₀H₁₅N₃O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 241.25

Ref: 3B-D3610

5-Methyl-2'-deoxycytidine, 99%

CAS: 838-07-3

5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar p

Formula: C₁₀H₁₅N₃O₄

Purity: 99%

Molecular weight: 241.24

Ref: 02-J65209

5-Methyl-2'-deoxycytidine

CAS: 838-07-3

Formula: C₁₀H₁₅N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 241.2438

Ref: IN-DA004WKC

5-Methyl-2''-deoxycytidine

CAS: 838-07-3

Formula: C₁₀H₁₅N₃O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 241.24

Ref: 7W-GE5158

2'-Deoxy-5-methylcytidine

CAS: 838-07-3

2'-Deoxy-5-methylcytidine

Purity: 98%

Molecular weight: 241.24g/mol

Ref: 54-OR40355

5-Methyl-2'-deoxycytidine

CAS: 838-07-3

5-Methyl-2'-deoxycytidine

Purity: ≥98%

Molecular weight: 241.24g/mol

Ref: 54-BUP18292

Cytidine Impurity 3 (5-Methyl-2'-Deoxycytidine)

CAS: 838-07-3

Formula: C₁₀H₁₅N₃O₄

Molecular weight: 241.25

Ref: 4Z-C-4510

5-Methyl-2'-deoxycytidine

CAS: 838-07-3

5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.

Formula: C₁₀H₁₅N₃O₄

Purity: 99.18% - 99.69%

Color and Shape: Solid

Molecular weight: 241.24

Ref: TM-T7457

5-Methyl-2’-deoxy Cytidine-13C,15N2

Controlled Product

CAS: 838-07-3

Formula: CC₉H₁₅₁₅N₂NO₄

Color and Shape: Off White Solid

Molecular weight: 244.22

Ref: TR-M295904

5-Methyl-2’-deoxy Cytidine

CAS: 838-07-3

Applications A Cytidine (C998300) analog and also an isostere of Thymidine (T412000).
References Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008),

Formula: C₁₀H₁₅N₃O₄

Color and Shape: Neat

Molecular weight: 241.24

Ref: TR-M295900

2'-Deoxy-5-methylcytidine

CAS: 838-07-3

2'-Deoxy-5-methylcytidine is a nucleoside analogue that inhibits the synthesis of DNA. It prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine has been shown to inhibit colon cancer cells in vitro, and may be a potential biomarker for bowel disease. This drug is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.

Formula: C₁₀H₁₅N₃O₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 241.25 g/mol

Ref: 3D-ND06242

4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one

CAS: 838-07-3

Formula: C₁₀H₁₅N₃O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 241.247

Ref: 10-F093448