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CAS 83805-11-2

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Falecalcitriol

Description:
Falecalcitriol, with the CAS number 83805-11-2, is a synthetic analog of calcitriol, which is the active form of vitamin D. It exhibits similar biological activity to calcitriol but is designed to have enhanced potency and a more favorable safety profile. This compound primarily functions as a vitamin D receptor agonist, promoting calcium absorption in the intestines and regulating bone metabolism. Falecalcitriol is utilized in the treatment of conditions related to calcium deficiency, such as osteoporosis and certain types of rickets. Its mechanism of action involves modulating gene expression related to calcium and phosphate homeostasis. Additionally, it may have immunomodulatory effects, making it a subject of interest in research related to autoimmune diseases. The compound is typically administered in a controlled dosage to minimize potential side effects, which can include hypercalcemia and hyperphosphatemia. Overall, falecalcitriol represents a significant advancement in vitamin D therapy, offering potential benefits in managing various metabolic bone disorders.
Formula:C27H38F6O3
InChI:InChI=1S/C27H38F6O3/c1-16(6-4-13-25(36,26(28,29)30)27(31,32)33)21-10-11-22-18(7-5-12-24(21,22)3)8-9-19-14-20(34)15-23(35)17(19)2/h8-9,16,20-23,34-36H,2,4-7,10-15H2,1,3H3/b18-8+,19-9-/t16-,20-,21-,22+,23+,24-/m1/s1
InChI key:InChIKey=XPYGGHVSFMUHLH-UUSULHAXSA-N
SMILES:C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCC(C(F)(F)F)(C(F)(F)F)O)C)[H])[H]
Synonyms:
  • (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta,25-triol
  • (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol
  • (1R,4S,5Z)-4-Methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  • (1S,3R,5Z,7E)-26,26,26,27,27,27-hexafluoro-9,10-secocholesta-5,7,10-triene-1,3,25-triol
  • 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,4S,5Z)-
  • 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3
  • 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D<sub>3</sub>
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1-alpha,3-beta,5Z,7E)-
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-
  • F<sub>6</sub>-1α,25-Dihydroxyvitamin D<sub>3</sub>
  • See more synonyms
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