CAS 83851-42-7

Leukotriene F4

Description:

Leukotriene F4 (LTF4) is a bioactive lipid mediator that plays a significant role in inflammatory responses and immune system regulation. It is a member of the leukotriene family, which are derived from arachidonic acid through the lipoxygenase pathway. LTF4 is characterized by its potent pro-inflammatory properties, contributing to various physiological processes, including bronchoconstriction, increased vascular permeability, and recruitment of immune cells to sites of inflammation. This compound is typically produced by leukocytes, particularly during allergic reactions and asthma. Its structure includes a series of conjugated double bonds and a carboxylic acid group, which are crucial for its biological activity. LTF4 is known to interact with specific leukotriene receptors, influencing cellular signaling pathways. Due to its involvement in pathological conditions, it has been a target for therapeutic interventions aimed at managing asthma and other inflammatory diseases. Understanding the characteristics and functions of LTF4 is essential for developing strategies to modulate its effects in various clinical settings.

Formula: C₂₈H₄₄N₂O₈S

InChI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22-,23-,24+/m0/s1

InChI key: InChIKey=PYSODLWHFWCFLV-VJBFNVCUSA-N

SMILES: [C@H](SC[C@H](NC(CC[C@@H](C(O)=O)N)=O)C(O)=O)([C@H](CCCC(O)=O)O)/C=C/C=C/C=C\C/C=C\CCCCC

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Cysteine, <smallcap>L</span>-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-
• <span class="text-smallcaps">L</smallcap>-Cysteine, <smallcap>L</span>-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-
• <span class="text-smallcaps">L</smallcap>-Cysteine, S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-<smallcap>L</span>-γ-glutamyl-, [R-[R*,S*-(E,E,Z,Z)]]-
• <span class="text-smallcaps">L</smallcap>-γ-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-<smallcap>L</span>-cysteine
• D-gamma-glutamyl-S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine
• L-cysteine, S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-L-g-glutamyl-,[R-[R*,S*-(E,E,Z,Z)]]-
• L-gamma-glutamyl-S-{(2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine
• Leukotriene F₄
• L-γ-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteine
• L-Cysteine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-
• Leukotriene F4

Leukotriene F4

Controlled Product

CAS: 83851-42-7

Formula: C₂₈H₄₄N₂O₈S

Color and Shape: Neat

Molecular weight: 568.723

Ref: TR-L330385

Leukotriene F4

CAS: 83851-42-7

LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.

Formula: C₂₈H₄₄N₂O₈S

Color and Shape: Solid

Molecular weight: 568.72

Ref: TM-T38129