CAS 83856-13-7

mast cell degranulating peptide

Description:

Mast cell degranulating peptide (CAS 83856-13-7) is a biologically active peptide that plays a significant role in the immune response, particularly in the activation and degranulation of mast cells. This peptide is derived from the venom of certain species, such as the wasp, and is known to induce the release of histamine and other inflammatory mediators from mast cells. Characteristically, it is a small peptide composed of a specific sequence of amino acids that facilitates its interaction with mast cell receptors. The biological activity of mast cell degranulating peptide is primarily associated with allergic reactions and inflammatory processes, making it a subject of interest in immunology and allergy research. Its ability to provoke mast cell degranulation can lead to various physiological effects, including vasodilation and increased vascular permeability. Due to its potent effects, it is also studied for potential therapeutic applications in modulating immune responses. However, its use is primarily confined to research settings, and safety considerations are paramount due to its inflammatory properties.

Formula: C₁₁₀H₁₉₂N₄₀O₂₄S₄

InChI: InChI=1/C110H192N40O24S4/c1-11-58(7)83(118)103(169)136-66(30-17-22-38-113)94(160)142-77-53-176-175-51-75(89(155)128-50-82(153)131-64(28-15-20-36-111)90(156)138-71(88(119)154)46-80(116)151)144-106(172)85(59(8)12-2)147-95(161)67(31-18-23-39-114)132-92(158)68(33-25-41-126-109(120)121)135-100(166)78-54-178-177-52-76(143-96(162)74(47-81(117)152)140-101(77)167)99(165)134-65(29-16-21-37-112)91(157)133-69(34-26-42-127-110(122)123)93(159)139-72(44-62-48-124-55-129-62)97(163)146-84(57(5)6)104(170)149-87(61(10)14-4)105(171)137-70(32-19-24-40-115)108(174)150-43-27-35-79(150)102(168)141-73(45-63-49-125-56-130-63)98(164)148-86(60(9)13-3)107(173)145-78/h48-49,55-79,83-87H,11-47,50-54,111-115,118H2,1-10H3,(H2,116,151)(H2,117,152)(H2,119,154)(H,128,155)(H,131,153)(H,132,158)(H,133,157)(H,134,165)(H,135,166)(H,136,169)(H,137,171)(H,138,156)(H,139,159)(H,140,167)(H,141,168)(H,142,160)(H,143,162)(H,144,172)(H,145,173)(H,146,163)(H,147,161)(H,148,164)(H,149,170)(H4,120,121,126)(H4,122,123,127)

SMILES: CCC(C)C(C(=NC(CCCCN)C(=NC1CSSCC(C(=NCC(=NC(CCCCN)C(=NC(CC(=N)O)C(=N)O)O)O)O)N=C(C(C(C)CC)N=C(C(CCCCN)N=C(C(CCCNC(=N)N)N=C(C2CSSCC(C(=NC(CCCCN)C(=NC(CCCNC(=N)N)C(=NC(CC3C=NC=N3)C(=NC(C(C)C)C(=NC(C(C)CC)C(=NC(CCCCN)C(=O)N3CCCC3C(=NC(CC3C=NC=N3)C(=NC(C(C)CC)C(=N2)O)O)O)O)O)O)O)O)O)N=C(C(CC(=N)O)N=C1O)O)O)O)O)O)O)O)N

Synonyms:

• Peptide
• Mast cell degranulating peptide (honeybee reduced) cyclic (3-15),(5-19)-bis(disulfide)
• Peptide 401
• MCD peptide
• Mast cell degranulating peptide (honeybee)