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CAS 83891-03-6

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Norfluoxetine

Description:
Norfluoxetine is a chemical compound that serves as an active metabolite of fluoxetine, a widely used selective serotonin reuptake inhibitor (SSRI) for the treatment of depression and anxiety disorders. It is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and fluorine atoms, contributing to its pharmacological properties. Norfluoxetine exhibits a high affinity for the serotonin transporter, effectively inhibiting the reuptake of serotonin in the synaptic cleft, thereby increasing serotonin levels in the brain. This mechanism is crucial for its antidepressant effects. The compound is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. Norfluoxetine has a relatively long half-life, which allows for sustained therapeutic effects. Additionally, it may have a lower side effect profile compared to its parent compound, fluoxetine, although individual responses can vary. Its safety and efficacy have been evaluated in various clinical studies, making it an important substance in psychopharmacology. As with any medication, it is essential to consider potential interactions and contraindications when prescribing norfluoxetine.
Formula:C16H16F3NO
InChI:InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2
InChI key:InChIKey=WIQRCHMSJFFONW-UHFFFAOYSA-N
SMILES:C(OC1=CC=C(C(F)(F)F)C=C1)(CCN)C2=CC=CC=C2
Synonyms:
  • 1-(3-Amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene
  • 3-Phenyl-3-[4-(Trifluoromethyl)Phenoxy]Propan-1-Amine
  • Benzenepropanamine, γ-[4-(trifluoromethyl)phenoxy]-
  • Desmethylfluoxetine
  • Norfluoxetine
  • γ-[4-(Trifluoromethyl)phenoxy]benzenepropanamine
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