CAS 83898-65-1

Domperidone maleate

Description:

Domperidone maleate is a pharmaceutical compound primarily used as an antiemetic and gastroprokinetic agent. It is a white to off-white crystalline powder that is soluble in water and alcohol, making it suitable for various formulations, including oral tablets and suspensions. The substance acts as a dopamine D2 receptor antagonist, primarily affecting the gastrointestinal tract, which helps to alleviate nausea and vomiting by enhancing gastric motility. Domperidone maleate is often prescribed for conditions such as gastroparesis and to manage side effects of certain medications. Its pharmacokinetics indicate that it has a relatively low oral bioavailability due to extensive first-pass metabolism, but it is well-tolerated with a favorable safety profile. Common side effects may include dry mouth, abdominal cramps, and, in rare cases, extrapyramidal symptoms. As with any medication, it is essential to use domperidone maleate under medical supervision to mitigate potential risks and interactions with other drugs.

Formula: C₂₂H₂₄ClN₅O₂·C₄H₄O₄

InChI: InChI=1S/C22H24ClN5O2.C4H4O4/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29;5-3(6)1-2-4(7)8/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=OAUUYDZHCOULIO-BTJKTKAUSA-N

SMILES: O=C1N(C=2C(N1)=CC(Cl)=CC2)C3CCN(CCCN4C=5C(NC4=O)=CC=CC5)CC3.C(=C\C(O)=O)\C(O)=O

Synonyms:

• 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (2Z)-2-butenedioate (1:1)
• 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (Z)-2-butenedioate (1:1)
• 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one (2Z)-but-2-enedioate
• Domperidone maleate
• 5-Chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one maleate

DOMPERIDONE MALEATE CRS

CAS: 83898-65-1

DOMPERIDONE MALEATE CRS

Formula: C₂₂H₂₄ClN₅O₂

Color and Shape: White. Whitish. Powder.

Molecular weight: 425.9113

Ref: 41-D2957000

Domperidone maleate

CAS: 83898-65-1

Domperidone maleate

Formula: C₂₂H₂₄ClN₅O₂

Purity: 78.2% for UV / 78.0% for HPLC

Color and Shape: White

Molecular weight: 425.16185

Ref: 47-669

Domperidone monomaleate

CAS: 83898-65-1

Domperidone monomaleate, a selective oral dopamine-2 antagonist, aids gastric motility and has antiemetic properties.

Formula: C₂₆H₂₈ClN₅O₆

Color and Shape: Solid

Molecular weight: 541.98

Ref: TM-T63819

Domperidone Maleate

CAS: 83898-65-1

Applications Domperidone maleate (CAS# 99497-03-7); a form of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
References Baudry, M., et al.: Arch. Pharmacol., 308, 231 (1979), Ennis, C., et al.: J. Pharm. Pharmacol., 31, 14 (1979), Brogden, R.N., Drugs, 24, 360 (1982),

Formula: C₂₂H₂₄ClN₅O₂·C₄H₄O₄

Color and Shape: White

Molecular weight: 425.91 + 116.07

Ref: TR-D531118