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CAS 83915-83-7

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Lisinopril dihydrate

Description:
Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is a white to off-white crystalline powder that is soluble in water, which facilitates its absorption in the body. The chemical formula for lisinopril dihydrate reflects its dihydrate form, indicating the presence of two water molecules associated with each lisinopril molecule. This compound works by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Lisinopril dihydrate is typically administered orally and is known for its long half-life, allowing for once-daily dosing. Common side effects may include dizziness, headache, and gastrointestinal disturbances, while serious adverse effects can involve renal impairment and hyperkalemia. As with any medication, it is essential to monitor patients for potential interactions with other drugs and underlying health conditions. Overall, lisinopril dihydrate is a widely used and effective medication in managing cardiovascular diseases.
Formula:C21H31N3O5·2H2O
InChI:InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
InChI key:InChIKey=CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
SMILES:C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCCN)(=O)N2[C@H](C(O)=O)CCC2.O
Synonyms:
  • N~2~-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline dihydrate
  • N-[2-[4-[[[(Cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]5-methylpyrazinecarboxamide dihydrate
  • N~2~-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline dihydrate
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, dihydrate
  • Lisinopril dihydrate
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2)
  • L-Proline, 1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-, dihydrate, (S)-
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