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CAS 83919-23-7

:

Mometasone furoate

Description:
Mometasone furoate is a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It is primarily used in the treatment of various inflammatory skin conditions, allergic rhinitis, and asthma. The compound exhibits a high affinity for glucocorticoid receptors, which enhances its efficacy in reducing inflammation and immune responses. Mometasone furoate is characterized by its low systemic bioavailability when administered topically, minimizing potential side effects associated with systemic corticosteroids. It is typically formulated as a cream, ointment, or nasal spray, allowing for targeted delivery to affected areas. The substance is known for its stability and solubility in organic solvents, which facilitates its incorporation into various pharmaceutical formulations. Additionally, it has a favorable safety profile, making it suitable for both short-term and long-term use in appropriate dosages. As with all corticosteroids, careful consideration of dosage and duration of treatment is essential to mitigate potential side effects, such as skin thinning or adrenal suppression, particularly with prolonged use.
Formula:C32H32Cl2O8
InChI:InChI=1/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18?,19?,21+,24+,25+,26+,27+/m1/s1
InChI key:InChIKey=WOFMFGQZHJDGCX-ZULDAHANSA-N
SMILES:O(C(=O)C1=CC=CO1)[C@@]2(C(CCl)=O)[C@]3(C)[C@@](C[C@H]2C)([C@]4([C@](Cl)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]
Synonyms:
  • (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
  • (8Xi,11Beta,14Xi,16Alpha)-9,21-Dichloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Furan-2-Carboxylate
  • 9-Chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate
  • Asmanex
  • Asmanex Twisthaler
  • Ecural
  • Elocom
  • Elocon
  • Elomet
  • Mometasone 17-(2-furoate)
  • See more synonyms
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