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CAS 84000-09-9

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N-Fmoc-N-ethyl-L-alanine

Description:
N-Fmoc-N-ethyl-L-alanine is a derivative of the amino acid L-alanine, characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protective group on the nitrogen atom of the amino group and an ethyl group attached to the same nitrogen. This compound is commonly used in peptide synthesis as a protecting group for the amino functionality, allowing for selective reactions without interfering with the amine. The Fmoc group is particularly advantageous due to its stability under basic conditions and its ease of removal under mild acidic conditions. N-Fmoc-N-ethyl-L-alanine is typically a white to off-white solid and is soluble in organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), but less soluble in water. Its molecular structure contributes to its utility in solid-phase peptide synthesis, where it helps in the formation of peptides with specific sequences. Additionally, the ethyl substitution can influence the steric and electronic properties of the resulting peptides, potentially affecting their biological activity.
Formula:C20H21NO4
Synonyms:
  • N-Fmoc-N-ethyl-L-alanine
  • Fmoc-N-Et-Ala-OH
  • L-Alanine, N-ethyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • (2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid
  • Fmoc-N-Et-L-Ala-OH
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