CAS 841290-81-1

R406

CAS: 841290-81-1

Formula: C₂₈H₂₉FN₆O₈S

Purity: 98%

Color and Shape: Solid

Molecular weight: 628.6287

Ref: IN-DA00G3PP

R406

CAS: 841290-81-1

R406

Purity: ≥95%

Molecular weight: 628.63g/mol

Ref: 54-BUP04252

6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-Yl)Amino)-2,2-Dimethyl-2H-Pyrido[3,2-b][1,4]Oxazin-3(4H)-One Benzenesulfonate

CAS: 841290-81-1

6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-Yl)Amino)-2,2-Dimethyl-2H-Pyrido[3,2-b][1,4]Oxazin-3(4H)-One Benzenesulfonate

Purity: 98%

Molecular weight: 628.63g/mol

Ref: 54-PC108892

R406

CAS: 841290-81-1

R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.

Formula: C₂₂H₂₃FN₆O₅·C₆H₆O₃S

Purity: 97.67% - 98.82%

Color and Shape: Solid

Molecular weight: 628.63

Ref: TM-T6174

R406

CAS: 841290-81-1

Applications R406 is a potent Syk inhibitor which affects Dectin-1-mediated signalling in mammilian cells. R406 thus acts an anti-fungal agent. Also a potential anti-leukemia agent, through modulation of sphingosine-1 phosphate receptor 1 (S1PR1).
References Borge, M. et al.: J. Immunol., 193, 3165 (2014); Kimura, Y. et al.: J. Biol. Chem., 289, 31565 (2014);

Formula: C₂₂H₂₃FN₆O₅·(C₆H₆O₃S)

Color and Shape: Light Brown

Molecular weight: 470.45 + (158.18)

Ref: TR-R060000

R 406

CAS: 841290-81-1

Inhibitor of SYK kinase

Formula: C₂₂H₂₃FN₆O₅•C₆H₆O₃S

Purity: Min. 95%

Molecular weight: 628.63 g/mol

Ref: 3D-FR103901