CAS 84211-05-2

MafosfaMide

Description:

Mafosfamide, with the CAS number 84211-05-2, is a chemotherapeutic agent that belongs to the class of alkylating agents. It is a prodrug of the active compound, which is a derivative of nitrogen mustard. Mafosfamide is primarily used in the treatment of certain types of cancers, including lymphomas and solid tumors. Its mechanism of action involves the formation of DNA cross-links, which ultimately leads to the inhibition of DNA synthesis and cell division, thereby exerting its cytotoxic effects on rapidly dividing cancer cells. The compound is typically administered intravenously and is known for its ability to penetrate tissues effectively. However, like many chemotherapeutic agents, mafosfamide can have significant side effects, including myelosuppression, gastrointestinal disturbances, and potential toxicity to other organs. Its use requires careful monitoring and management of adverse effects. Overall, mafosfamide represents an important option in the arsenal of cancer therapies, particularly for patients who may benefit from its specific action on tumor cells.

Formula: C₉H₂₀Cl₂N₂NaO₅PS₂

Synonyms:

• Mafosfamide Sodium Salt (Mixture of Diastereomers)
• sodium:2-[[(2R,4R)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2$l^{5}-oxazaphosphinan-4-yl]sulfanyl]ethanesulfonate
• Mafosfamide Sodium Salt

Mafosfamide Sodium Salt

Controlled Product

CAS: 84211-05-2

Stability Moisture Sensitive, Very Hygroscopic
Applications A Cyclophosphamide analog which induces apoptosis dose and time dependently in lymphoblastoid cells, with clearly more apoptosis in p53wt cells. Antitumor agent.
References Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999), Lips, J., et al.: Carcinogenesis, 22, 579 (2001), Ward, I., et al.: J. Biol. Chem., 276, 47759 (2001), Zhou, B., et al.: Cancer Biol. Ther., 2, S16 (2003), Roos, W., et al.: Oncogene, 26, 186 (2007),

Formula: C₉H₁₈Cl₂N₂NaO₅PS₂

Color and Shape: White To Light Beige

Molecular weight: 423.24

Ref: TR-M110300

Mafosfamide sodium

CAS: 84211-05-2

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Formula: C₉H₁₉Cl₂N₂O₅PS₂•Na

Purity: Min. 95%

Molecular weight: 424.26 g/mol

Ref: 3D-FM182718

Mafosfamide sodium

CAS: 84211-05-2

Mafosfamide, a synthetic antineoplastic, alkylates DNA without needing liver activation. Useful for neoplastic meningitis.

Formula: C₉H₁₈Cl₂N₂NaO₅PS₂

Color and Shape: Solid

Molecular weight: 423.24

Ref: TM-T68592