CAS 842133-18-0

Canagliflozin

Description:

Canagliflozin is a medication primarily used in the management of type 2 diabetes mellitus. It belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, which function by preventing the reabsorption of glucose in the kidneys, thereby promoting its excretion in urine and lowering blood glucose levels. The chemical formula for Canagliflozin is C21H25ClO5S, and it features a sulfonyl group, a chlorobenzene moiety, and a glucose-like structure, which contribute to its pharmacological activity. Canagliflozin is typically administered orally and is known for its potential benefits beyond glycemic control, including weight loss and cardiovascular protection. Common side effects may include urinary tract infections and dehydration. As with any medication, it is essential for patients to consult healthcare professionals for personalized advice and monitoring while using Canagliflozin.

Formula: C₂₄H₂₅FO₅S

InChI: InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1

InChI key: InChIKey=XTNGUQKDFGDXSJ-ZXGKGEBGSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC=3SC(=CC3)C4=CC=C(F)C=C4)=C(C)C=C2

Synonyms:

• (1S)-1,5-Anhydro-1-C-(3-((5-(4-Fluorophenyl)-2-Thienyl)Methyl)-4-Methylphenyl)-D-Glucitol
• (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-<span class="text-smallcaps">D</span>-glucitol
• 1-(β-<span class="text-smallcaps">D</span>-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
• 1-(β-D-glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienyl-methyl) benzene
• <span class="text-smallcaps">D</span>-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-
• Canaglifozin
• Invokana
• Jnj 24831754Zae
• Jnj 28431754
• Jnj 28431754Aaa
• Ta 7284
• Canagliflozin
• D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-
• D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl
• (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
• Canagliflozi
• Cango coluMn net
• Canagliflozin WS
• Canagliflozin, >=98%
• Canaglifozion
• Canagliflozin-D6
• Canagliflozin(TA-7284)

Canagliflozin

CAS: 842133-18-0

Canagliflozin

Purity: ≥98%

Molecular weight: 444.52g/mol

Ref: 54-BUP17778

Canagliflozin

CAS: 842133-18-0

Canagliflozin

Purity: 99%

Molecular weight: 444.52g/mol

Ref: 54-PC108773

Canagliflozin

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₅S

Color and Shape: Off-White Solid

Molecular weight: 444.52

Ref: 4Z-C-152002

Canagliflozin

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₅S

Purity: ≥ 98.0%

Color and Shape: White to yellow solid

Molecular weight: 444.52

Ref: 7W-GX8313

CANAGLIFLOZIN

CAS: 842133-18-0

Purity: 95%

Color and Shape: Solid

Molecular weight: 444.519989013672

Ref: 10-F857122

Canagliflozin

CAS: 842133-18-0

Color and Shape: Neat

Ref: 86-MM3870.00

Canagliflozin

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₅S

Color and Shape: Neat

Molecular weight: 444.52

Ref: 04-CA10945450

Canagliflozin-13C6

CAS: 842133-18-0

Formula: C₁₈₁₃C₆H₂₅FO₅S

Molecular weight: 450.47

Ref: 4Z-C-152049

Canagliflozin

CAS: 842133-18-0

Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor. Canagliflozin is used to treat type II diabetes mellitus. Cost-effective and quality-assured.

Formula: C₂₄H₂₅FO₅S

Purity: 98.01% - >99.99%

Color and Shape: Solid

Molecular weight: 444.52

Ref: TM-T1782

Canagliflozin

Controlled Product

CAS: 842133-18-0

Applications Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);

Formula: C₂₄H₂₅FO₅S

Color and Shape: Colourless

Molecular weight: 444.52

Ref: TR-C175190

1,5-Dihydroxy Canagliflozin

Controlled Product

CAS: 842133-18-0

Formula: C₂₄H₂₇FO₆S

Color and Shape: Neat

Molecular weight: 462.531

Ref: TR-D450431

Canagliflozin

CAS: 842133-18-0

Canagliflozin is a drug that has been approved for the treatment of type 2 diabetes. It is an inhibitor of sodium glucose transporter 2 (SGLT2) and reduces blood glucose levels by increasing urinary glucose excretion. Canagliflozin has been shown to have cardiac effects, which may be due to its ability to increase serum natriuretic peptide levels and decrease heart rate. This drug has also been shown to reduce cardiovascular disease activity in patients with type 2 diabetes. Canagliflozin is not active against c. glabrata, but it does inhibit SGLT1 in this organism.

Formula: C₂₄H₂₅FO₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 444.52 g/mol

Ref: 3D-MC58356

2'-Deshydroxymethyl-2'-Chloromethyl-6'-methoxy-canagliflozin

Controlled Product

CAS: 842133-18-0

Formula: C₂₅H₂₆ClFO₅S

Color and Shape: Neat

Molecular weight: 492.987

Ref: TR-D221670

2'-Deshydroxymethyl-2'-Chloromethyl-canagliflozin

Controlled Product

CAS: 842133-18-0

Formula: C₂₄H₂₄ClFO₄S

Color and Shape: Neat

Molecular weight: 462.961

Ref: TR-D221665

(3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-2-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Controlled Product

CAS: 842133-18-0

Formula: C₂₅H₂₇FO₆S

Color and Shape: Neat

Molecular weight: 474.542

Ref: TR-F953260

Canagliflozin Tetra-acetyloxy

Controlled Product

CAS: 842133-18-0

Formula: C₃₂H₃₃FO₉S

Color and Shape: Neat

Molecular weight: 612.662

Ref: TR-C175204

(2R,3R,4R,5R)-1-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2,3,4,5,6-pentahydroxyhexan-1-one

Controlled Product

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₆S

Color and Shape: Neat

Molecular weight: 460.515

Ref: TR-F590211