CAS 843-93-6

4(3H)-Quinazolinone,3-(4-bromo-2-methylphenyl)-2-methyl-

Description:

4(3H)-Quinazolinone, 3-(4-bromo-2-methylphenyl)-2-methyl- is a chemical compound characterized by its quinazolinone core structure, which is a bicyclic compound containing both a benzene and a pyrimidine ring. The presence of the 4-bromo-2-methylphenyl group introduces significant steric and electronic effects, influencing the compound's reactivity and potential biological activity. This compound typically exhibits properties such as moderate solubility in organic solvents and may have limited solubility in water due to its hydrophobic aromatic components. It is often studied for its potential pharmacological applications, particularly in medicinal chemistry, where quinazolinone derivatives are known for their diverse biological activities, including anti-inflammatory and anticancer properties. The presence of bromine and methyl groups can enhance lipophilicity and alter the compound's interaction with biological targets. Safety data should be consulted for handling and usage, as halogenated compounds can pose specific health risks. Overall, this compound represents a class of heterocyclic compounds with significant interest in drug discovery and development.

Formula: C₁₆H₁₃BrN₂O

Synonyms:

• 4(3H)-Quinazolinone,3-(4-bromo-o-tolyl)-2-methyl- (6CI,7CI,8CI)
• Cp 10447

CP-10447

CAS: 843-93-6

Applications CP-10447 is an inhibitor apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2) by inhibiting MTP activity and stimulating the early ER degradation of apoB. It is useful tool for further study of the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.
References Haghpassand, M. et al.: J. Lipid. Res., 37, 1468 (1996); Pan, M. et al.: J. Biol. chem., 275, 27399 (2000);

Formula: C₁₆H₁₃BrN₂O

Color and Shape: Neat

Molecular weight: 329.19

Ref: TR-C781200

CP 10447

Controlled Product

CAS: 843-93-6

Inhibitor of microsomal triglyceride transfer protein

Formula: C₁₆H₁₃BrN₂O

Purity: Min. 95%

Molecular weight: 329.19 g/mol

Ref: 3D-FC20579

CP-10447

CAS: 843-93-6

CP-10447 inhibits apoB and triglyceride secretion in HepG2 cells by blocking MTP and promoting apoB degradation, aiding lipoprotein assembly studies.

Formula: C₁₆H₁₃BrN₂O

Color and Shape: Solid

Molecular weight: 329.19

Ref: TM-T68588