CAS 843663-66-1

Bedaquiline

Description:

Bedaquiline is an antitubercular medication primarily used in the treatment of multidrug-resistant tuberculosis (MDR-TB). It is classified as a diarylquinoline and functions by inhibiting the ATP synthase enzyme in Mycobacterium tuberculosis, disrupting the bacterium's energy production. This mechanism of action is unique compared to traditional TB treatments, making Bedaquiline a valuable option in cases where other therapies have failed. The compound is typically administered orally and has a long half-life, allowing for once-daily dosing. Bedaquiline is known for its potential side effects, which may include nausea, headache, and QT interval prolongation, necessitating careful monitoring of cardiac health during treatment. Its use is generally recommended in combination with other anti-TB agents to prevent the development of resistance. Due to its specific application and mechanism, Bedaquiline represents a significant advancement in the fight against drug-resistant tuberculosis, addressing a critical need in global health.

Formula: C₃₂H₃₁BrN₂O₂

InChI: InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

InChI key: InChIKey=QUIJNHUBAXPXFS-XLJNKUFUSA-N

SMILES: [C@]([C@@H](C=1C(OC)=NC2=C(C1)C=C(Br)C=C2)C3=CC=CC=C3)(CCN(C)C)(O)C=4C5=C(C=CC4)C=CC=C5

Synonyms:

• (αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
• 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)-
• 6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
• Bedaquiline
• R-207910
• Sirturo
• Tmc-207

Bedaquiline

CAS: 843663-66-1

Bedaquiline

Formula: C₃₂H₃₁BrN₂O₂

Purity: By hplc: 99.8% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 555.50g/mol

Ref: 54-BISN0131

Bedaquiline

CAS: 843663-66-1

Bedaquiline

Purity: ≥98%

Molecular weight: 555.5g/mol

Ref: 54-BUP10565

Bedaquiline

CAS: 843663-66-1

Molecular weight: 555.515991210938

Ref: 10-F957690

Bedaquiline

CAS: 843663-66-1

Bedaquiline, an anti-TB drug, blocks mycobacterial ATP synthesis, effective against all Mycobacterium tuberculosis states.

Formula: C₃₂H₃₁BrN₂O₂

Purity: 98% - 99.8%

Color and Shape: Solid

Molecular weight: 555.5

Ref: TM-T2585

(AlphaS,BetaR)-Bedaquiline

Controlled Product

CAS: 843663-66-1

Applications (aS,bR)-Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.
References Cheepsattayakorn, A., et al.: Anti-Infect. Drug. Discover.,7, 141 (2012); de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);

Formula: C₃₂H₃₁BrN₂O₂

Color and Shape: White To Light Yellow

Molecular weight: 555.50

Ref: TR-B119540

Bedaquiline

CAS: 843663-66-1

Bedaquiline is a drug that inhibits the synthesis of mycobacterial RNA by binding to the ribosomal subunit. It is used to treat tuberculosis and multidrug-resistant tuberculosis. Bedaquiline has been shown to be bactericidal against wild-type strains of Mycobacterium tuberculosis and Mycobacterium avium complex, but not against multidrug-resistant strains of these bacteria. Bedaquiline also interacts with other drugs that inhibit the cytochrome P450 system, such as cycloserine or rifampin. Bedaquiline is active against MDR-TB but not against extensively drug resistant TB (XDR-TB).

Formula: C₃₂H₃₁BrN₂O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 555.5 g/mol

Ref: 3D-FB46540