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CAS 84418-35-9

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N-Nitrosopropranolol

Description:
N-Nitrosopropranolol is a nitrosamine derivative of propranolol, a non-selective beta-adrenergic antagonist commonly used to treat hypertension and anxiety. This compound is characterized by its nitrosamine functional group, which is formed by the reaction of a secondary amine (in this case, propranolol) with nitrous acid. N-Nitrosopropranolol is of particular interest due to its potential carcinogenic properties, as many nitrosamines are known to be hazardous. The compound typically appears as a pale yellow solid or crystalline substance and is soluble in organic solvents. Its stability can be influenced by environmental factors such as pH and temperature. In terms of safety, exposure to nitrosamines is generally considered a health risk, prompting regulatory scrutiny. Research into N-Nitrosopropranolol focuses on its formation, biological activity, and implications for human health, especially in relation to the use of propranolol and similar medications. Understanding its characteristics is crucial for assessing risks associated with its presence in pharmaceutical formulations and the environment.
Formula:C16H20N2O3
InChI:InChI=1S/C16H20N2O3/c1-12(2)18(17-20)10-14(19)11-21-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,19H,10-11H2,1-2H3
InChI key:InChIKey=TXYRHXNLIUKPMM-UHFFFAOYSA-N
SMILES:O(CC(CN(C(C)C)N=O)O)C=1C2=C(C=CC1)C=CC=C2
Synonyms:
  • (E)-2-[2-hydroxy-3-(naphthalen-1-yloxy)propyl]-2-(propan-2-yl)diazen-2-iumolate
  • 1-[(1-Methylethyl)nitrosoamino]-3-(1-naphthalenyloxy)-2-propanol
  • 2-Propanol, 1-[(1-methylethyl)nitrosoamino]-3-(1-naphthalenyloxy)-
  • N-Nitrosopropranolol
  • diazenium, 2-hydroxy-1-[2-hydroxy-3-(1-naphthalenyloxy)propyl]-1-(1-methylethyl)-, inner salt, (E)-
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